FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301316457> ?p ?o ?g. }

• W2301316457 endingPage "208" @default.
• W2301316457 startingPage "196" @default.
• W2301316457 abstract "High-fat diet (HFD) induced obesity is associated not only with metabolic dysregulation, e.g., impaired glucose homeostasis and insulin sensitivity, but also with neurological dysfunction manifested with aberrant behavior and/or neurotransmitter imbalance. Most studies have examined HFD's effects predominantly in male subjects, either in the periphery or on the brain, in isolation and after a finite feeding period. In this study, we evaluated the time-course of selected metabolic, behavioral, and neurochemical effects of HFD intake in parallel and at multiple time points in female (C57BL/6) mice. Peripheral effects were evaluated at three feeding intervals (short: 5-6 weeks, long: 20-22 weeks, and prolonged: 33-36 weeks). Central effects were evaluated only after long and prolonged feeding durations; we have previously reported those effects after the short (5-6 weeks) feeding duration. Ongoing HFD feeding resulted in an obese phenotype characterized by increased visceral adiposity and, after prolonged HFD intake, an increase in liver and kidney weights. Peripherally, 5 weeks of HFD intake was sufficient to impair glucose tolerance significantly, with the deleterious effects of HFD being greater with prolonged intake. Similarly, 5 weeks of HFD consumption was sufficient to impair insulin sensitivity. However, sensitivity to insulin after prolonged HFD intake was not different between control, low-fat diet (LFD) and HFD-fed mice, most likely due to age-dependent decrease in insulin sensitivity in the LFD-fed mice. HFD intake also induced bi-phasic hepatic inflammation and it increased gut permeability. Behaviorally, prolonged intake of HFD caused mice to be hypoactive and bury fewer marbles in a marble burying task; the latter was associated with significantly impaired hippocampal serotonin homeostasis. Cognitive (short-term recognition memory) function of mice was unaffected by chronic HFD feeding. Considering our prior findings of short-term (5-6 weeks) HFD-induced central (hyperactivity/anxiety and altered ventral hippocampal neurochemistry) effects and our current results, it seems that in female mice some metabolic/inflammatory dysregulations caused by HFD, such as gut permeability, appear early and persist, whereas others, such as glucose intolerance, are exaggerated with continuous HFD feeding; behaviorally, prolonged HFD consumption mainly affects locomotor activity and anxiety-like responses, likely due to the advanced obesity phenotype; neurochemically, the serotonergic system appears to be most sensitive to continued HFD feeding." @default.
• W2301316457 created "2016-06-24" @default.
• W2301316457 creator A5000950737 @default.
• W2301316457 creator A5002691323 @default.
• W2301316457 creator A5015210155 @default.
• W2301316457 creator A5016109138 @default.
• W2301316457 creator A5026895542 @default.
• W2301316457 creator A5027521470 @default.
• W2301316457 creator A5030092188 @default.
• W2301316457 creator A5045870241 @default.
• W2301316457 creator A5062746683 @default.
• W2301316457 creator A5088345942 @default.
• W2301316457 date "2016-04-01" @default.
• W2301316457 modified "2023-10-12" @default.
• W2301316457 title "Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake" @default.
• W2301316457 cites W100734209 @default.
• W2301316457 cites W1498962687 @default.
• W2301316457 cites W1518051697 @default.
• W2301316457 cites W1556392272 @default.
• W2301316457 cites W1599925064 @default.
• W2301316457 cites W1606612235 @default.
• W2301316457 cites W1822601256 @default.
• W2301316457 cites W1923361084 @default.
• W2301316457 cites W1939789398 @default.
• W2301316457 cites W1956899762 @default.
• W2301316457 cites W1964032272 @default.
• W2301316457 cites W1965021718 @default.
• W2301316457 cites W1972622243 @default.
• W2301316457 cites W1972697711 @default.
• W2301316457 cites W1978774769 @default.
• W2301316457 cites W1980519483 @default.
• W2301316457 cites W1981459575 @default.
• W2301316457 cites W1985020422 @default.
• W2301316457 cites W1987299915 @default.
• W2301316457 cites W1991838121 @default.
• W2301316457 cites W1992265643 @default.
• W2301316457 cites W1993082280 @default.
• W2301316457 cites W1993083632 @default.
• W2301316457 cites W1996694057 @default.
• W2301316457 cites W1997146137 @default.
• W2301316457 cites W1997342739 @default.
• W2301316457 cites W1999149427 @default.
• W2301316457 cites W1999835438 @default.
• W2301316457 cites W2000054651 @default.
• W2301316457 cites W2004415631 @default.
• W2301316457 cites W2005689441 @default.
• W2301316457 cites W2005996584 @default.
• W2301316457 cites W2006505627 @default.
• W2301316457 cites W2006526695 @default.
• W2301316457 cites W2013117639 @default.
• W2301316457 cites W2015358846 @default.
• W2301316457 cites W2015911699 @default.
• W2301316457 cites W2017712441 @default.
• W2301316457 cites W2019858347 @default.
• W2301316457 cites W2021187035 @default.
• W2301316457 cites W2023595618 @default.
• W2301316457 cites W2027508239 @default.
• W2301316457 cites W2028906037 @default.
• W2301316457 cites W2029375375 @default.
• W2301316457 cites W2030628693 @default.
• W2301316457 cites W2031425628 @default.
• W2301316457 cites W2034532609 @default.
• W2301316457 cites W2035059971 @default.
• W2301316457 cites W2039401785 @default.
• W2301316457 cites W2040106495 @default.
• W2301316457 cites W2040213984 @default.
• W2301316457 cites W2042183374 @default.
• W2301316457 cites W2048980693 @default.
• W2301316457 cites W2050661152 @default.
• W2301316457 cites W2050838727 @default.
• W2301316457 cites W2054098071 @default.
• W2301316457 cites W2056393440 @default.
• W2301316457 cites W2060977160 @default.
• W2301316457 cites W2065240281 @default.
• W2301316457 cites W2069702946 @default.
• W2301316457 cites W2073279468 @default.
• W2301316457 cites W2077616550 @default.
• W2301316457 cites W2082130856 @default.
• W2301316457 cites W2083218589 @default.
• W2301316457 cites W2084610168 @default.
• W2301316457 cites W2086073611 @default.
• W2301316457 cites W2086573866 @default.
• W2301316457 cites W2087395189 @default.
• W2301316457 cites W2087931458 @default.
• W2301316457 cites W2088666203 @default.
• W2301316457 cites W2090409064 @default.
• W2301316457 cites W2091793050 @default.
• W2301316457 cites W2092474731 @default.
• W2301316457 cites W2093500882 @default.
• W2301316457 cites W2096334197 @default.
• W2301316457 cites W2096876054 @default.
• W2301316457 cites W2098176910 @default.
• W2301316457 cites W2099729330 @default.
• W2301316457 cites W2099934660 @default.
• W2301316457 cites W2104296301 @default.
• W2301316457 cites W2105676684 @default.
• W2301316457 cites W2110463517 @default.
• W2301316457 cites W2112620654 @default.

• next