Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301375031> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2301375031 abstract "Wound healing involves the stringent spatial and temporal coordination of several processes including directional cell migration, the extracellular matrix remodeling, and the angiogenesis. Recently, migration stimulating factor (MSF) has been reported to stimulate the migration of fibroblasts, epithelial and endothelial cells, where the corresponding cell response is mediated by the binding of the MSF to integrin αVβ3 receptor. However, wound healing can be delayed when patients are unable to produce wound healing cytokines, such as epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and MSF. In this study, we propose a nanotechnology-based approach to monitoring the real-time integrin αVβ3 signal pathway involved in wound healing and its relationship to cytoskeleton. We apply a MSF-like fluorescent small molecule probe MM-IGD-Fl-2 to stain and identify the distribution of integrin αVβ3 in living human dermal fibroblast cells CCD-996SK. We then utilize the biofunctionalized quntum dots (QDs) conjugated with MSF-like small molecule MM-IGD-Az-2 to provide a more direct access to probing the spatiotemporal distribution of QD-MM-IGD-Az-2-integrin αVβ3 complexes. Accordingly, the signal pathway activated after binding of MM-IGD-Az-2 to integrin αVβ3 receptor could be traced. On the other hand, to synchronize cellular responses and to eliminate the possibility of receptor-mediated internalization, CCD-996SK cells are incubated with QD-MM-IGD-Az-2 at 4°C, followed by further incubation at 37 °C in a temperature controlled flow chamber. We anticipate the proposed approach to be a starting point for more sophisticated in the mechanisms of wound healing at the cellular level." @default.
- W2301375031 created "2016-06-24" @default.
- W2301375031 creator A5079964105 @default.
- W2301375031 date "2016-02-01" @default.
- W2301375031 modified "2023-09-29" @default.
- W2301375031 title "Real-Time Probing of Integrin αVβ3 Signal Pathway Involved in Wound Healing using Biofunctionalized Quantum Dots" @default.
- W2301375031 doi "https://doi.org/10.1016/j.bpj.2015.11.536" @default.
- W2301375031 hasPublicationYear "2016" @default.
- W2301375031 type Work @default.
- W2301375031 sameAs 2301375031 @default.
- W2301375031 citedByCount "0" @default.
- W2301375031 crossrefType "journal-article" @default.
- W2301375031 hasAuthorship W2301375031A5079964105 @default.
- W2301375031 hasBestOaLocation W23013750311 @default.
- W2301375031 hasConcept C137738243 @default.
- W2301375031 hasConcept C1491633281 @default.
- W2301375031 hasConcept C170493617 @default.
- W2301375031 hasConcept C185592680 @default.
- W2301375031 hasConcept C189165786 @default.
- W2301375031 hasConcept C195687474 @default.
- W2301375031 hasConcept C202751555 @default.
- W2301375031 hasConcept C203014093 @default.
- W2301375031 hasConcept C2778005187 @default.
- W2301375031 hasConcept C2780269544 @default.
- W2301375031 hasConcept C2780381497 @default.
- W2301375031 hasConcept C2780394083 @default.
- W2301375031 hasConcept C502942594 @default.
- W2301375031 hasConcept C55493867 @default.
- W2301375031 hasConcept C86803240 @default.
- W2301375031 hasConcept C95444343 @default.
- W2301375031 hasConceptScore W2301375031C137738243 @default.
- W2301375031 hasConceptScore W2301375031C1491633281 @default.
- W2301375031 hasConceptScore W2301375031C170493617 @default.
- W2301375031 hasConceptScore W2301375031C185592680 @default.
- W2301375031 hasConceptScore W2301375031C189165786 @default.
- W2301375031 hasConceptScore W2301375031C195687474 @default.
- W2301375031 hasConceptScore W2301375031C202751555 @default.
- W2301375031 hasConceptScore W2301375031C203014093 @default.
- W2301375031 hasConceptScore W2301375031C2778005187 @default.
- W2301375031 hasConceptScore W2301375031C2780269544 @default.
- W2301375031 hasConceptScore W2301375031C2780381497 @default.
- W2301375031 hasConceptScore W2301375031C2780394083 @default.
- W2301375031 hasConceptScore W2301375031C502942594 @default.
- W2301375031 hasConceptScore W2301375031C55493867 @default.
- W2301375031 hasConceptScore W2301375031C86803240 @default.
- W2301375031 hasConceptScore W2301375031C95444343 @default.
- W2301375031 hasLocation W23013750311 @default.
- W2301375031 hasOpenAccess W2301375031 @default.
- W2301375031 hasPrimaryLocation W23013750311 @default.
- W2301375031 hasRelatedWork W1622106176 @default.
- W2301375031 hasRelatedWork W1969240457 @default.
- W2301375031 hasRelatedWork W1981284178 @default.
- W2301375031 hasRelatedWork W1998650818 @default.
- W2301375031 hasRelatedWork W2009852602 @default.
- W2301375031 hasRelatedWork W2014941639 @default.
- W2301375031 hasRelatedWork W2044501211 @default.
- W2301375031 hasRelatedWork W2051842090 @default.
- W2301375031 hasRelatedWork W2054408547 @default.
- W2301375031 hasRelatedWork W2061732759 @default.
- W2301375031 hasRelatedWork W2064426281 @default.
- W2301375031 hasRelatedWork W2074600512 @default.
- W2301375031 hasRelatedWork W2078968211 @default.
- W2301375031 hasRelatedWork W2086405067 @default.
- W2301375031 hasRelatedWork W2109582895 @default.
- W2301375031 hasRelatedWork W2112104969 @default.
- W2301375031 hasRelatedWork W2158316283 @default.
- W2301375031 hasRelatedWork W2313857734 @default.
- W2301375031 hasRelatedWork W3168138064 @default.
- W2301375031 hasRelatedWork W87910691 @default.
- W2301375031 isParatext "false" @default.
- W2301375031 isRetracted "false" @default.
- W2301375031 magId "2301375031" @default.
- W2301375031 workType "article" @default.