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- W2301415099 abstract "Host-microbial symbioses are vital to health; nonetheless, little is known about the role crosskingdom signaling plays in these relationships. In a process called quorum sensing, bacteria communicate with one another using extracellular signal molecules called autoinducers. One autoinducer, AI-2, is proposed to promote interspecies bacterial communication, including in the mammalian gut. We show that mammalian epithelia produce an AI-2 mimic activity in response to bacteria or tight-junction disruption. This AI-2 mimic is detected by the bacterial AI-2 receptor, LuxP/LsrB, and can activate quorum-sensing-controlled gene expression, including in the enteric pathogen Salmonella typhimurium. AI-2 mimic activity is induced when epithelia are directly or indirectly exposed to bacteria, suggesting that a secreted bacterial component(s) stimulates its production. Mutagenesis revealed genes required for bacteria to both detect and stimulate production of the AI-2 mimic. These findings uncover a potential role for the mammalian AI-2 mimic in fostering crosskingdom signaling and host-bacterial symbioses." @default.
- W2301415099 created "2016-06-24" @default.
- W2301415099 creator A5014532272 @default.
- W2301415099 creator A5034726213 @default.
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- W2301415099 date "2016-04-01" @default.
- W2301415099 modified "2023-10-14" @default.
- W2301415099 title "A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing" @default.
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- W2301415099 doi "https://doi.org/10.1016/j.chom.2016.02.020" @default.
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