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W2301478824 abstract "// Jana Jezkova 1, * , Jason S. Williams 1, * , Filipe Pinto 2, 3 , Stephen J. Sammut 1 , Geraint T. Williams 4 , Simon Gollins 5 , Ramsay J. McFarlane 1, 6 , Rui Manuel Reis 2, 3, 7 , Jane A. Wakeman 1 1 North West Cancer Research Institute, School of Medical Sciences, Bangor University, Bangor, UK 2 Life and Health Sciences Research Institute (ICVS), School Health Sciences, University Minho, Braga, Portugal 3 ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal 4 Institute of Cancer and Genetics, Cardiff University Medical School, Cardiff, UK 5 North Wales Cancer Treatment Centre, Betsi Cadwaladr University Health Board, Bodelwyddan, UK 6 NISCHR Cancer Genetics Biomedical Research Unit, Cardiff, UK 7 Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil * These authors contributed equally to this work Correspondence to: Jane A. Wakeman, e-mail: j.a.wakeman@bangor.ac.uk Keywords: Brachyury, enteroendocrine cells, small intestine/colon, crypts, colorectal cancer Received: September 16, 2015 Accepted: January 23, 2016 Published: February 05, 2016 ABSTRACT Normal homeostasis of adult intestinal epithelium and repair following tissue damage is maintained by a balance of stem and differentiated cells, many of which are still only poorly characterised. Enteroendocrine cells of the gut are a small population of differentiated, secretory cells that are critical for integrating nutrient sensing with metabolic responses, dispersed amongst other epithelial cells. Recent evidence suggests that sub-sets of secretory enteroendocrine cells can act as reserve stem cells. Given the link between cells with stem-like properties and cancer, it is important that we identify factors that might provide a bridge between the two. Here, we identify a sub-set of chromogranin A-positive enteroendocrine cells that are positive for the developmental and cancer-associated transcription factor Brachyury in normal human small intestinal and colonic crypts. Whilst chromogranin A-positive enteroendocrine cells are also Brachyury-positive in colorectal tumours, expression of Brachyury becomes more diffuse in these samples, suggesting a more widespread function in cancer. The finding of the developmental transcription factor Brachyury in normal adult human intestinal crypts may extend the functional complexity of enteroendocrine cells and serves as a platform for assessment of the molecular processes of intestinal homeostasis that underpins our understanding of human health, cancer and aging." @default.
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W2301478824 date "2016-02-05" @default.
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W2301478824 title "Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer" @default.
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W2301478824 doi "https://doi.org/10.18632/oncotarget.7202" @default.
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