Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301486290> ?p ?o ?g. }
- W2301486290 endingPage "1178" @default.
- W2301486290 startingPage "1174" @default.
- W2301486290 abstract "Cucurbit[7]uril (CB[7]) was found in vitro to sequester the neurotoxins MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP(+) (N-methyl-4-phenylpyridine). The CB[7]/neurotoxin host-guest complexes were studied in detail with (1)H NMR, electrospray ionization mass spectrometry, UV-visible spectroscopic titration, and molecular modeling by density functional theory. The results supported the macrocyclic encapsulation of MPTP and MPP(+), respectively, by CB[7] in aqueous solutions with relatively strong affinities and 1:1 host-guest binding stoichiometries in both cases. More importantly, the progression of MPTP/MPP(+) induced neurodegeneration (often referred to as a Parkinson's disease model) was observed to be strongly inhibited in vivo by the synthetic CB[7] receptor, as shown in zebrafish models. These results show that a supramolecular approach could lead to a new preventive and/or therapeutic strategy for counteracting the deleterious effects of some neurotoxins leading to neurodegeneration." @default.
- W2301486290 created "2016-06-24" @default.
- W2301486290 creator A5001354647 @default.
- W2301486290 creator A5010592992 @default.
- W2301486290 creator A5023317620 @default.
- W2301486290 creator A5025346338 @default.
- W2301486290 creator A5027416136 @default.
- W2301486290 creator A5035430155 @default.
- W2301486290 creator A5053935265 @default.
- W2301486290 creator A5065352657 @default.
- W2301486290 date "2015-10-19" @default.
- W2301486290 modified "2023-10-18" @default.
- W2301486290 title "Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor" @default.
- W2301486290 cites W1502339857 @default.
- W2301486290 cites W151483826 @default.
- W2301486290 cites W1578829945 @default.
- W2301486290 cites W1823160350 @default.
- W2301486290 cites W1938622267 @default.
- W2301486290 cites W1954070107 @default.
- W2301486290 cites W1964803346 @default.
- W2301486290 cites W1969800514 @default.
- W2301486290 cites W1976723967 @default.
- W2301486290 cites W1980048463 @default.
- W2301486290 cites W2006568020 @default.
- W2301486290 cites W2014659473 @default.
- W2301486290 cites W2024005625 @default.
- W2301486290 cites W2031315586 @default.
- W2301486290 cites W2031483889 @default.
- W2301486290 cites W2032131270 @default.
- W2301486290 cites W2038654846 @default.
- W2301486290 cites W2038690111 @default.
- W2301486290 cites W2047191671 @default.
- W2301486290 cites W2057119353 @default.
- W2301486290 cites W2068900925 @default.
- W2301486290 cites W2070416424 @default.
- W2301486290 cites W2080737507 @default.
- W2301486290 cites W2088537098 @default.
- W2301486290 cites W2089260204 @default.
- W2301486290 cites W2102361084 @default.
- W2301486290 cites W2106471696 @default.
- W2301486290 cites W2128281537 @default.
- W2301486290 cites W2134586168 @default.
- W2301486290 cites W2135129422 @default.
- W2301486290 cites W2135860971 @default.
- W2301486290 cites W2139902274 @default.
- W2301486290 cites W2141422001 @default.
- W2301486290 cites W2145271930 @default.
- W2301486290 cites W2152165298 @default.
- W2301486290 cites W2164050728 @default.
- W2301486290 cites W2314911900 @default.
- W2301486290 cites W2809722643 @default.
- W2301486290 doi "https://doi.org/10.1021/acsmedchemlett.5b00372" @default.
- W2301486290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4677361" @default.
- W2301486290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26713100" @default.
- W2301486290 hasPublicationYear "2015" @default.
- W2301486290 type Work @default.
- W2301486290 sameAs 2301486290 @default.
- W2301486290 citedByCount "48" @default.
- W2301486290 countsByYear W23014862902016 @default.
- W2301486290 countsByYear W23014862902017 @default.
- W2301486290 countsByYear W23014862902018 @default.
- W2301486290 countsByYear W23014862902019 @default.
- W2301486290 countsByYear W23014862902020 @default.
- W2301486290 countsByYear W23014862902021 @default.
- W2301486290 countsByYear W23014862902022 @default.
- W2301486290 countsByYear W23014862902023 @default.
- W2301486290 crossrefType "journal-article" @default.
- W2301486290 hasAuthorship W2301486290A5001354647 @default.
- W2301486290 hasAuthorship W2301486290A5010592992 @default.
- W2301486290 hasAuthorship W2301486290A5023317620 @default.
- W2301486290 hasAuthorship W2301486290A5025346338 @default.
- W2301486290 hasAuthorship W2301486290A5027416136 @default.
- W2301486290 hasAuthorship W2301486290A5035430155 @default.
- W2301486290 hasAuthorship W2301486290A5053935265 @default.
- W2301486290 hasAuthorship W2301486290A5065352657 @default.
- W2301486290 hasBestOaLocation W23014862904 @default.
- W2301486290 hasConcept C12554922 @default.
- W2301486290 hasConcept C142724271 @default.
- W2301486290 hasConcept C162356407 @default.
- W2301486290 hasConcept C178790620 @default.
- W2301486290 hasConcept C184866935 @default.
- W2301486290 hasConcept C185592680 @default.
- W2301486290 hasConcept C21951064 @default.
- W2301486290 hasConcept C2776925932 @default.
- W2301486290 hasConcept C2778674702 @default.
- W2301486290 hasConcept C2779134260 @default.
- W2301486290 hasConcept C2779734285 @default.
- W2301486290 hasConcept C2780358027 @default.
- W2301486290 hasConcept C32909587 @default.
- W2301486290 hasConcept C40684141 @default.
- W2301486290 hasConcept C43617362 @default.
- W2301486290 hasConcept C55493867 @default.
- W2301486290 hasConcept C71240020 @default.
- W2301486290 hasConcept C71924100 @default.
- W2301486290 hasConcept C86803240 @default.
- W2301486290 hasConcept C93275456 @default.
- W2301486290 hasConceptScore W2301486290C12554922 @default.
- W2301486290 hasConceptScore W2301486290C142724271 @default.