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- W2301500360 abstract "To determine the reference ranges and developmental pattern of liver enzymes and serum lipids, serum samples of 1127 hepatitis B surface antigen (HBsAg) -negative, apparently healthy Chinese children aged from 2 days to 14 years were tested for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phoshatase (ALP), triglyceride (TG) and cholesterol (CHO) with an autoanalyzer (Hitachi Model 716, Tokyo). Reference ranges for each test were established by using a nonparametric statistical method. Mean AST activity was higher in infancy, decreased gradually in subsequent age groups and approached the lowest level at 11-14 years. Mean ALT activity was always lower and less age-dependent than AST and became more stable after one to two years of age. Age-dependent variation was observed throughout childhood for the mean ALP activity, and a sex difference occurred, particularly after 12 years of age. Peak activities in girls occurred at 11 years, followed by a sharp decline to the adult level within a few years, whereas more pronounced peak activities in boys occurred between 11-13 years without much subsequent alteration. Chinese children had ALP activities as high as four times the upper adult limit. Mean serum TG in boys varied minimally from 3 to 10 years, achieved its highest level of 73 mg/dl at 12 years, then sharply decreased through age 13 to the lowest level at 14 years. In girls, there was a sharp increment in mean TG level from age 8 to 11, followed by a rapid decline to preadolescent level at 14 years. Mean level of serum CHO reached a low adult level in early infancy, remained relatively stable from age 4-10 years, with a range from 158 to 167 mg/dl. Mean CHO concentration tended to fall in both sexes between 11 to 14 years of age." @default.
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- W2301500360 date "1986-08-01" @default.
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- W2301500360 title "The Biochemical Profile of Liver Function Tests in Normal Chinese Infants and Children II. Liver Enzymes and Serum Lipids" @default.
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