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- W2301606685 abstract "Neurogenesis in Drosophila occurs in two phases, embryonic and post-embryonic, in which the same set of neuroblasts give rise to the distinct larval and adult nervous systems, respectively. Here, we identified the embryonic neuroblast origin of the adult neuronal lineages in the ventral nervous system via lineage-specific GAL4 lines and molecular markers. Our lineage mapping revealed that neurons born late in the embryonic phase show axonal morphology and transcription factor profiles that are similar to the neurons born post-embryonically from the same neuroblast. Moreover, we identified three thorax-specific neuroblasts not previously characterized and show that HOX genes confine them to the thoracic segments. Two of these, NB2-3 and NB3-4, generate leg motor neurons. The other neuroblast is novel and appears to have arisen recently during insect evolution. Our findings provide a comprehensive view of neurogenesis and show how proliferation of individual neuroblasts is dictated by temporal and spatial cues." @default.
- W2301606685 created "2016-06-24" @default.
- W2301606685 creator A5027466213 @default.
- W2301606685 creator A5047219343 @default.
- W2301606685 date "2016-03-15" @default.
- W2301606685 modified "2023-10-16" @default.
- W2301606685 title "Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system" @default.
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- W2301606685 doi "https://doi.org/10.7554/elife.13399" @default.
- W2301606685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4805552" @default.
- W2301606685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26975248" @default.
- W2301606685 hasPublicationYear "2016" @default.
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