FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301647511> ?p ?o ?g. }

• W2301647511 endingPage "7523" @default.
• W2301647511 startingPage "7515" @default.
• W2301647511 abstract "The high-mobility group protein A2 (HMGA2) is an architectural transcription factor that plays a crucial role in the development and progression of various malignant cancers. However, the function of HMGA2 in bladder cancer remains largely unknown. Therefore, we aim to investigate the effect of HMGA2 on the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of bladder cancer cells. The expression of HMGA2 in human bladder cancer cells was downregulated by small interfering RNA (siRNA). The protein levels of HMGA2 and other related proteins were detected by Western blotting. The cell proliferation and apoptosis were examined by Cell Counting Kit-8 and flow cytometry, respectively. Transwell migration and invasion assays were performed to assess the effect of HMGA2 on the migration and invasion ability of cells. In conclusion, we found that HMGA2 knockdown markedly inhibited cell proliferation; this reduced cell growth was due to the high apoptosis rate of cells, as Bcl-xl was diminished, whereas Bax was upregulated. Moreover, our results showed that silencing of HMGA2 in cancer cells greatly inhibited the cell migration and invasion, decreased the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), and affected the occurrence of EMT. We further found that decreased HMGA2 expression suppressed the transforming growth factor-β (TGF-β)/Smad and Wnt/β-catenin signaling pathway in bladder cancer cells. These results revealed that HMGA2 played an important role in the progression of bladder cancer and might be a novel target for therapy in human bladder cancer." @default.
• W2301647511 created "2016-06-24" @default.
• W2301647511 creator A5005192685 @default.
• W2301647511 creator A5007672814 @default.
• W2301647511 creator A5022051421 @default.
• W2301647511 creator A5033083323 @default.
• W2301647511 creator A5037537662 @default.
• W2301647511 creator A5064319844 @default.
• W2301647511 creator A5072809229 @default.
• W2301647511 date "2015-12-18" @default.
• W2301647511 modified "2023-10-14" @default.
• W2301647511 title "Silencing of HMGA2 suppresses cellular proliferation, migration, invasion, and epithelial–mesenchymal transition in bladder cancer" @default.
• W2301647511 cites W1077473103 @default.
• W2301647511 cites W1964081206 @default.
• W2301647511 cites W1965124005 @default.
• W2301647511 cites W1970195787 @default.
• W2301647511 cites W1999820088 @default.
• W2301647511 cites W2014191267 @default.
• W2301647511 cites W2047508350 @default.
• W2301647511 cites W2048835818 @default.
• W2301647511 cites W2050834003 @default.
• W2301647511 cites W2053296924 @default.
• W2301647511 cites W2062365157 @default.
• W2301647511 cites W2065105042 @default.
• W2301647511 cites W2068128343 @default.
• W2301647511 cites W2076002185 @default.
• W2301647511 cites W2076883636 @default.
• W2301647511 cites W2079189474 @default.
• W2301647511 cites W2086968193 @default.
• W2301647511 cites W2095599548 @default.
• W2301647511 cites W2106878555 @default.
• W2301647511 cites W2139211838 @default.
• W2301647511 cites W2155201542 @default.
• W2301647511 cites W2164358503 @default.
• W2301647511 cites W2168242356 @default.
• W2301647511 cites W2170552969 @default.
• W2301647511 cites W2172255896 @default.
• W2301647511 cites W2191676373 @default.
• W2301647511 cites W293548796 @default.
• W2301647511 doi "https://doi.org/10.1007/s13277-015-4625-2" @default.
• W2301647511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26684800" @default.
• W2301647511 hasPublicationYear "2015" @default.
• W2301647511 type Work @default.
• W2301647511 sameAs 2301647511 @default.
• W2301647511 citedByCount "36" @default.
• W2301647511 countsByYear W23016475112016 @default.
• W2301647511 countsByYear W23016475112017 @default.
• W2301647511 countsByYear W23016475112018 @default.
• W2301647511 countsByYear W23016475112019 @default.
• W2301647511 countsByYear W23016475112020 @default.
• W2301647511 countsByYear W23016475112021 @default.
• W2301647511 countsByYear W23016475112022 @default.
• W2301647511 countsByYear W23016475112023 @default.
• W2301647511 crossrefType "journal-article" @default.
• W2301647511 hasAuthorship W2301647511A5005192685 @default.
• W2301647511 hasAuthorship W2301647511A5007672814 @default.
• W2301647511 hasAuthorship W2301647511A5022051421 @default.
• W2301647511 hasAuthorship W2301647511A5033083323 @default.
• W2301647511 hasAuthorship W2301647511A5037537662 @default.
• W2301647511 hasAuthorship W2301647511A5064319844 @default.
• W2301647511 hasAuthorship W2301647511A5072809229 @default.
• W2301647511 hasConcept C104317684 @default.
• W2301647511 hasConcept C119056186 @default.
• W2301647511 hasConcept C121608353 @default.
• W2301647511 hasConcept C137620995 @default.
• W2301647511 hasConcept C137738243 @default.
• W2301647511 hasConcept C145059251 @default.
• W2301647511 hasConcept C1491633281 @default.
• W2301647511 hasConcept C173396325 @default.
• W2301647511 hasConcept C185592680 @default.
• W2301647511 hasConcept C190283241 @default.
• W2301647511 hasConcept C2529059 @default.
• W2301647511 hasConcept C2779013556 @default.
• W2301647511 hasConcept C2780352672 @default.
• W2301647511 hasConcept C2780699576 @default.
• W2301647511 hasConcept C502942594 @default.
• W2301647511 hasConcept C54355233 @default.
• W2301647511 hasConcept C55493867 @default.
• W2301647511 hasConcept C62112901 @default.
• W2301647511 hasConcept C62478195 @default.
• W2301647511 hasConcept C76419328 @default.
• W2301647511 hasConcept C86803240 @default.
• W2301647511 hasConcept C95444343 @default.
• W2301647511 hasConcept C96232424 @default.
• W2301647511 hasConceptScore W2301647511C104317684 @default.
• W2301647511 hasConceptScore W2301647511C119056186 @default.
• W2301647511 hasConceptScore W2301647511C121608353 @default.
• W2301647511 hasConceptScore W2301647511C137620995 @default.
• W2301647511 hasConceptScore W2301647511C137738243 @default.
• W2301647511 hasConceptScore W2301647511C145059251 @default.
• W2301647511 hasConceptScore W2301647511C1491633281 @default.
• W2301647511 hasConceptScore W2301647511C173396325 @default.
• W2301647511 hasConceptScore W2301647511C185592680 @default.
• W2301647511 hasConceptScore W2301647511C190283241 @default.
• W2301647511 hasConceptScore W2301647511C2529059 @default.
• W2301647511 hasConceptScore W2301647511C2779013556 @default.
• W2301647511 hasConceptScore W2301647511C2780352672 @default.
• W2301647511 hasConceptScore W2301647511C2780699576 @default.

• next