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- W2301743663 endingPage "5614" @default.
- W2301743663 startingPage "5597" @default.
- W2301743663 abstract "Arabidopsis ESD7 locus encodes the catalytic subunit of the DNA Pol ϵ involved in the synthesis of the DNA leading strand and is essential for embryo viability. The hypomorphic allele esd7-1 is viable but displays a number of pleiotropic phenotypic alterations including an acceleration of flowering time. Furthermore, Pol ϵ is involved in the epigenetic silencing of the floral integrator genes FT and SOC1, but the molecular nature of the transcriptional gene silencing mechanisms involved remains elusive. Here we reveal that ESD7 interacts with components of the PRC2 such as CLF, EMF2 and MSI1, and that mutations in ESD7 cause a decrease in the levels of the H3K27me3 mark present in the chromatin of FT and SOC1. We also demonstrate that a domain of the C-terminal region of ESD7 mediates the binding to the different PRC2 components and this interaction is necessary for the proper recruitment of PRC2 to FT and SOC1 chromatin. We unveil the existence of interplay between the DNA replication machinery and the PcG complexes in epigenetic transcriptional silencing. These observations provide an insight into the mechanisms ensuring that the epigenetic code at pivotal loci in developmental control is faithfully transmitted to the progeny of eukaryotic cells." @default.
- W2301743663 created "2016-06-24" @default.
- W2301743663 creator A5008492856 @default.
- W2301743663 creator A5014237010 @default.
- W2301743663 creator A5025985855 @default.
- W2301743663 creator A5058480630 @default.
- W2301743663 creator A5081217694 @default.
- W2301743663 creator A5087759571 @default.
- W2301743663 date "2016-03-14" @default.
- W2301743663 modified "2023-10-15" @default.
- W2301743663 title "Arabidopsis DNA polymerase ϵ recruits components of Polycomb repressor complex to mediate epigenetic gene silencing" @default.
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