Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301796838> ?p ?o ?g. }
- W2301796838 abstract "Tumor protein D52 (TPD52) is amplified and/or overexpressed in cancers of diverse cellular origins. Altered cellular metabolism (including lipogenesis) is a hallmark of cancer development, and protein-protein associations between TPD52 and known regulators of lipid storage, and differential TPD52 expression in obese versus non-obese adipose tissue, suggest that TPD52 might regulate cellular lipid metabolism. We found increased lipid droplet numbers in BALB/c 3T3 cell lines stably expressing TPD52, compared with control and TPD52L1-expressing cell lines. TPD52-expressing 3T3 cells showed increased fatty acid storage in triglyceride (from both de novo synthesis and uptake) and formed greater numbers of lipid droplets upon oleic acid supplementation than control cells. TPD52 colocalised with Golgi, but not endoplasmic reticulum (ER), markers and also showed partial colocalisation with lipid droplets coated with ADRP (also known as PLIN2), with a proportion of TPD52 being detected in the lipid droplet fraction. Direct interactions between ADRP and TPD52, but not TPD52L1, were demonstrated using the yeast two-hybrid system, with ADRP-TPD52 interactions confirmed using GST pulldown assays. Our findings uncover a new isoform-specific role for TPD52 in promoting intracellular lipid storage, which might be relevant to TPD52 overexpression in cancer." @default.
- W2301796838 created "2016-06-24" @default.
- W2301796838 creator A5006270132 @default.
- W2301796838 creator A5007626604 @default.
- W2301796838 creator A5010669809 @default.
- W2301796838 creator A5016634905 @default.
- W2301796838 creator A5045484049 @default.
- W2301796838 creator A5055266843 @default.
- W2301796838 creator A5066602508 @default.
- W2301796838 creator A5066912379 @default.
- W2301796838 creator A5070238702 @default.
- W2301796838 creator A5082812084 @default.
- W2301796838 creator A5084971557 @default.
- W2301796838 creator A5045388265 @default.
- W2301796838 date "2015-01-01" @default.
- W2301796838 modified "2023-10-16" @default.
- W2301796838 title "TPD52 expression increases neutral lipid storage within cultured cells" @default.
- W2301796838 cites W1525804132 @default.
- W2301796838 cites W1538526318 @default.
- W2301796838 cites W1574080856 @default.
- W2301796838 cites W1828555256 @default.
- W2301796838 cites W1919512980 @default.
- W2301796838 cites W1945140151 @default.
- W2301796838 cites W1947112226 @default.
- W2301796838 cites W1963771790 @default.
- W2301796838 cites W1963838710 @default.
- W2301796838 cites W1964649812 @default.
- W2301796838 cites W1966383003 @default.
- W2301796838 cites W1968055555 @default.
- W2301796838 cites W1974730258 @default.
- W2301796838 cites W1977860917 @default.
- W2301796838 cites W1980568044 @default.
- W2301796838 cites W1987537017 @default.
- W2301796838 cites W1987737792 @default.
- W2301796838 cites W1990467031 @default.
- W2301796838 cites W1993738297 @default.
- W2301796838 cites W1997852780 @default.
- W2301796838 cites W2001803158 @default.
- W2301796838 cites W2007232689 @default.
- W2301796838 cites W2012019009 @default.
- W2301796838 cites W2012383052 @default.
- W2301796838 cites W2017258167 @default.
- W2301796838 cites W2018020283 @default.
- W2301796838 cites W2018391923 @default.
- W2301796838 cites W2018912187 @default.
- W2301796838 cites W2019229986 @default.
- W2301796838 cites W2019981157 @default.
- W2301796838 cites W2022986290 @default.
- W2301796838 cites W2023430066 @default.
- W2301796838 cites W2023445541 @default.
- W2301796838 cites W2030901818 @default.
- W2301796838 cites W2034781186 @default.
- W2301796838 cites W2034930832 @default.
- W2301796838 cites W2041210709 @default.
- W2301796838 cites W2041506421 @default.
- W2301796838 cites W2045912282 @default.
- W2301796838 cites W2045983090 @default.
- W2301796838 cites W2059275312 @default.
- W2301796838 cites W2060905615 @default.
- W2301796838 cites W2061063821 @default.
- W2301796838 cites W2067940817 @default.
- W2301796838 cites W2069839376 @default.
- W2301796838 cites W2073049760 @default.
- W2301796838 cites W2074478038 @default.
- W2301796838 cites W2075792257 @default.
- W2301796838 cites W2077813812 @default.
- W2301796838 cites W2079343474 @default.
- W2301796838 cites W2079474262 @default.
- W2301796838 cites W2083613192 @default.
- W2301796838 cites W2084081368 @default.
- W2301796838 cites W2085529001 @default.
- W2301796838 cites W2089681519 @default.
- W2301796838 cites W2091224218 @default.
- W2301796838 cites W2091284643 @default.
- W2301796838 cites W2097259163 @default.
- W2301796838 cites W2100253993 @default.
- W2301796838 cites W2106189539 @default.
- W2301796838 cites W2106843579 @default.
- W2301796838 cites W2110096707 @default.
- W2301796838 cites W2112877739 @default.
- W2301796838 cites W2117657395 @default.
- W2301796838 cites W2121233961 @default.
- W2301796838 cites W2126472136 @default.
- W2301796838 cites W2126486316 @default.
- W2301796838 cites W2132757463 @default.
- W2301796838 cites W2136180772 @default.
- W2301796838 cites W2141265612 @default.
- W2301796838 cites W2142166377 @default.
- W2301796838 cites W2147483302 @default.
- W2301796838 cites W2149056596 @default.
- W2301796838 cites W2149227522 @default.
- W2301796838 cites W2153178365 @default.
- W2301796838 cites W2153284029 @default.
- W2301796838 cites W2156100443 @default.
- W2301796838 cites W2159651857 @default.
- W2301796838 cites W2160412430 @default.
- W2301796838 cites W2160992936 @default.
- W2301796838 cites W2167624431 @default.
- W2301796838 cites W2168526937 @default.
- W2301796838 cites W2169429756 @default.