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- W2301992938 abstract "Background: As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA). Material & methods: A group of six male adolescents with a diagnosis of primary, recurrent/residual JA was enrolled in the study. All patients underwent 68 Ga-DOTATATE PET/computed tomography (CT) followed by immunohistochemical staining for SSTR expression. Results: 68 Ga-DOTATATE PET/CT showed accumulation in areas matching the pathologic tissue in the nasopharynx of all patients studied with SUV max of 5.1 ± 0.9 (ranging from 3.6 to 6.4). In all cases, the immunohistochemical examination showed a presence of SSTR2A with a high staining index. Conclusion: In vitro SSTR2A cytoplasm expression was found to be high in all tumor specimens. However, the uptake of 68 Ga-DOTATATE was weak in the PET/CT studies. We postulate that the intracellular localization of the SSTR2A in JA may cause this discrepancy." @default.
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- W2301992938 date "2016-06-01" @default.
- W2301992938 modified "2023-10-17" @default.
- W2301992938 title "68Ga-DOTATATE PET in juvenile angiofibroma" @default.
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- W2301992938 doi "https://doi.org/10.2217/fon-2015-0074" @default.
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