FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302260618> ?p ?o ?g. }

• W2302260618 endingPage "e0149685" @default.
• W2302260618 startingPage "e0149685" @default.
• W2302260618 abstract "Background The quantification of brain atrophy in relapsing-remitting multiple sclerosis (RRMS) may serve as a marker of disease progression and treatment response. We compared the association between first-line (FL) or second-line (SL) disease-modifying drugs (DMDs) and brain volume changes over time in RRMS. Materials and Methods We reviewed clinical trials in RRMS between January 1, 1995 and June 1, 2014 that assessed the effect of DMDs and reported data on brain atrophy in Medline, Embase, the Cochrane database and meeting abstracts. First, we designed a meta-analysis to directly compare the percentage brain volume change (PBVC) between FLDMDs and SLDMDs at 24 months. Second, we conducted an observational and longitudinal linear regression analysis of a 48-month follow-up period. Sensitivity analyses considering PBVC between 12 and 48 months were also performed. Results Among the 272 studies identified, 117 were analyzed and 35 (18,140 patients) were included in the analysis. Based on the meta-analysis, atrophy was greater for the use of an FLDMD than that of an SLDMD at 24 months (primary endpoint mean difference, -0.86; 95% confidence interval: -1.57–-0.15; P = 0.02). Based on the linear regression analysis, the annual PBVC significantly differed between SLDMDs and placebo (-0.27%/y and -0.50%/y, respectively, P = 0.046) but not between FLDMDs (-0.33%/y) and placebo (P = 0.11) or between FLDMDs and SLDMDs (P = 0.49). Based on sensitivity analysis, the annual PBVC was reduced for SLDMDs compared with placebo (-0.14%/y and -0.56%/y, respectively, P<0.001) and FLDMDs (-0.46%/y, P<0.005), but no difference was detected between FLDMDs and placebo (P = 0.12). Conclusions SLDMDs were associated with reduced PBVC slope over time in RRMS, regardless of the period considered. These results provide new insights into the mechanisms underlying atrophy progression in RRMS." @default.
• W2302260618 created "2016-06-24" @default.
• W2302260618 creator A5006997286 @default.
• W2302260618 creator A5022120259 @default.
• W2302260618 creator A5029201551 @default.
• W2302260618 creator A5061993323 @default.
• W2302260618 date "2016-03-16" @default.
• W2302260618 modified "2023-10-16" @default.
• W2302260618 title "The Effect of Disease-Modifying Drugs on Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: A Meta-Analysis" @default.
• W2302260618 cites W1567125068 @default.
• W2302260618 cites W1965458143 @default.
• W2302260618 cites W1966515383 @default.
• W2302260618 cites W1975385248 @default.
• W2302260618 cites W1981894990 @default.
• W2302260618 cites W1994083593 @default.
• W2302260618 cites W2006178657 @default.
• W2302260618 cites W2011178903 @default.
• W2302260618 cites W2019582599 @default.
• W2302260618 cites W2020502278 @default.
• W2302260618 cites W2026913491 @default.
• W2302260618 cites W2037636284 @default.
• W2302260618 cites W2042601306 @default.
• W2302260618 cites W2046748764 @default.
• W2302260618 cites W2054368151 @default.
• W2302260618 cites W2056796322 @default.
• W2302260618 cites W2067962939 @default.
• W2302260618 cites W2089793429 @default.
• W2302260618 cites W2098923148 @default.
• W2302260618 cites W2101483035 @default.
• W2302260618 cites W2122542523 @default.
• W2302260618 cites W2122545833 @default.
• W2302260618 cites W2132228594 @default.
• W2302260618 cites W2133679933 @default.
• W2302260618 cites W2140848986 @default.
• W2302260618 cites W2141185335 @default.
• W2302260618 cites W2142577589 @default.
• W2302260618 cites W2151340435 @default.
• W2302260618 cites W2151576334 @default.
• W2302260618 cites W2153132118 @default.
• W2302260618 cites W2153236082 @default.
• W2302260618 cites W2154915901 @default.
• W2302260618 cites W2158048836 @default.
• W2302260618 cites W2158202057 @default.
• W2302260618 cites W2165727662 @default.
• W2302260618 cites W2167170024 @default.
• W2302260618 cites W2333473854 @default.
• W2302260618 cites W2576440140 @default.
• W2302260618 cites W2588681363 @default.
• W2302260618 cites W3149634704 @default.
• W2302260618 doi "https://doi.org/10.1371/journal.pone.0149685" @default.
• W2302260618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4794160" @default.
• W2302260618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26983008" @default.
• W2302260618 hasPublicationYear "2016" @default.
• W2302260618 type Work @default.
• W2302260618 sameAs 2302260618 @default.
• W2302260618 citedByCount "25" @default.
• W2302260618 countsByYear W23022606182016 @default.
• W2302260618 countsByYear W23022606182017 @default.
• W2302260618 countsByYear W23022606182018 @default.
• W2302260618 countsByYear W23022606182019 @default.
• W2302260618 countsByYear W23022606182020 @default.
• W2302260618 countsByYear W23022606182021 @default.
• W2302260618 countsByYear W23022606182022 @default.
• W2302260618 countsByYear W23022606182023 @default.
• W2302260618 crossrefType "journal-article" @default.
• W2302260618 hasAuthorship W2302260618A5006997286 @default.
• W2302260618 hasAuthorship W2302260618A5022120259 @default.
• W2302260618 hasAuthorship W2302260618A5029201551 @default.
• W2302260618 hasAuthorship W2302260618A5061993323 @default.
• W2302260618 hasBestOaLocation W23022606181 @default.
• W2302260618 hasConcept C126322002 @default.
• W2302260618 hasConcept C142724271 @default.
• W2302260618 hasConcept C203014093 @default.
• W2302260618 hasConcept C204787440 @default.
• W2302260618 hasConcept C27081682 @default.
• W2302260618 hasConcept C2780640218 @default.
• W2302260618 hasConcept C2781172350 @default.
• W2302260618 hasConcept C3017906399 @default.
• W2302260618 hasConcept C44249647 @default.
• W2302260618 hasConcept C71924100 @default.
• W2302260618 hasConcept C95190672 @default.
• W2302260618 hasConceptScore W2302260618C126322002 @default.
• W2302260618 hasConceptScore W2302260618C142724271 @default.
• W2302260618 hasConceptScore W2302260618C203014093 @default.
• W2302260618 hasConceptScore W2302260618C204787440 @default.
• W2302260618 hasConceptScore W2302260618C27081682 @default.
• W2302260618 hasConceptScore W2302260618C2780640218 @default.
• W2302260618 hasConceptScore W2302260618C2781172350 @default.
• W2302260618 hasConceptScore W2302260618C3017906399 @default.
• W2302260618 hasConceptScore W2302260618C44249647 @default.
• W2302260618 hasConceptScore W2302260618C71924100 @default.
• W2302260618 hasConceptScore W2302260618C95190672 @default.
• W2302260618 hasIssue "3" @default.
• W2302260618 hasLocation W23022606181 @default.
• W2302260618 hasLocation W23022606182 @default.
• W2302260618 hasLocation W23022606183 @default.
• W2302260618 hasLocation W23022606184 @default.
• W2302260618 hasLocation W23022606185 @default.

• next