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- W2302308243 abstract "Abstract Natural killer (NK) cells kill cancer and virus-infected cells through their cytolytic activity. The last step in NK cell cytotoxicity, fusion of lytic granules with the plasma membrane resulting in exocytosis of granule content, is still poorly understood. Proteins from the SNARE family mediate all membrane fusion events in the cell. Here we show that NK cells express all seven members of the R-SNARE subgroup. Two of these R-SNARE proteins, VAMP4 and VAMP7, are associated with lytic granules during cytotoxic interactions. However, only VAMP7 co-localizes with granules in non-activated cells. The differences in co-localization of these two R-SNARE proteins, with respect to perforin-containing cytotoxic granules, indicate that they have different functions in exocytosis. Using the tumor NK cell line, YTS, we show that RNAi-mediated disruption of expression of either VAMP4 or VAMP7 inhibits release of lytic granules and severely impairs NK cell cytotoxic activity. Furthermore, VAMP7 but not VAMP4 is involved in cytokine secretion and endocytosis in NK cells, indicating that VAMP7 is involved in many fusion processes and thus plays a more general function in NK cell activity than VAMP4." @default.
- W2302308243 created "2016-06-24" @default.
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- W2302308243 date "2010-04-01" @default.
- W2302308243 modified "2023-10-17" @default.
- W2302308243 title "Both VAMP4 and VAMP7 are indispensable for NK cell cytotoxicity: the requirement for two R-SNARE proteins in granule exocytosis. (89.24)" @default.
- W2302308243 doi "https://doi.org/10.4049/jimmunol.184.supp.89.24" @default.
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