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• W2302323162 abstract "No AccessJournal of UrologyInvestigative Urology1 Sep 2016Chronic Prostatitis Induces Bladder Hypersensitivity and Sensitizes Bladder Afferents in the Mouse Erica S. Schwartz, Jun-Ho La, Erin E. Young, Bin Feng, Sonali Joyce, and G.F. Gebhart Erica S. SchwartzErica S. Schwartz More articles by this author , Jun-Ho LaJun-Ho La More articles by this author , Erin E. YoungErin E. Young More articles by this author , Bin FengBin Feng More articles by this author , Sonali JoyceSonali Joyce More articles by this author , and G.F. GebhartG.F. Gebhart More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.03.077AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Chronic prostatitis/chronic pelvic pain syndrome causes symptoms that include the frequent and urgent need to urinate, pain or burning during urination and pain radiating to the back, abdomen and/or colorectum. These bladder symptoms suggest that chronic prostatitis/chronic pelvic pain syndrome is associated with sensitization of adjacent organs, termed cross-organ sensitization. The objective of this study was to determine the extent of 1) changes in immunomodulatory mediators in the prostate and bladder after inflammation of the prostate and 2) bladder function and bladder afferent sensitization. Materials and Methods: Prostate and bladder histology, immunohistochemistry and expression of immunomodulatory targets were examined weekly after zymosan or vehicle was injected in the dorsal lobe of the mouse prostate. Cystometry, bladder and bladder afferent sensitivity were also assessed weekly. Results: Prostate inflammation induced significant up-regulation in proinflammatory and anti-inflammatory cytokines TNF-α (tumor necrosis factor-α) and IL-10 (interleukin-10), growth factor NGF (nerve growth factor), and T-lymphocyte markers FoxP3, CD4 and CD8 in the prostate and the bladder. Notably, prostatitis significantly increased urinary voiding frequency, induced hypersensitivity to bladder distension and sensitized bladder afferents. We also examined sensory (afferent) co-innervation by injecting retrograde tracers DiI and Fast Blue in the bladder wall and the prostate, respectively. This showed that a significant proportion (approximately 17%) of dorsal root ganglion afferent somata contained tracers from the bladder and the prostate. Conclusions: These observations support an afferent contribution to chronic prostatitis/chronic pelvic pain syndrome and cross-organ sensitization from prostate to bladder. References 1 : Pathophysiology of pain. In: Neurophysiology. Edited by . Philadelphia: Saunders1961: 350. Google Scholar 2 : A life of pelvic pain. Physiol Behav2005; 86: 272. Google Scholar 3 : Visceral organ cross-sensitization—an integrated perspective. Auton Neurosci2010; 153: 106. Google Scholar 4 : Colonic inflammation increases Na+ currents in bladder sensory neurons. Neuroreport2004; 15: 2601. Google Scholar 5 : A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. Gastroenterology2005; 128: 1953. Google Scholar 6 : Urogenital pain — time to accept a new approach to phenotyping and, as a consequence, management. Eur Urol2008; 53: 33. Google Scholar 7 : Chronic pelvis pain syndrome and the overactive bladder: the inflammatory link. Curr Urol Rep2008; 9: 314. Google Scholar 8 : Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol2008; 53: 60. Google Scholar 9 : Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis. PLoS One2012; 7: e41941. Google Scholar 10 : Nociceptive and Inflammatory mediator upregulation in a mouse model of chronic prostatitis. Pain2015; 156: 1537. Google Scholar 11 Schwartz ES, Young E, Feng B et al: Prostatitis induces bladder hypersensitivity via neural cross-talk. Presented at annual meeting of Society for Neuroscience, Washington, D.C., November 15-19, 2014, poster 628. Google Scholar 12 : Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology2011; 140: 1283. Google Scholar 13 : TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci2013; 27: 5603. Google Scholar 14 : Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon. Neuroscience2011; 186: 179. Google Scholar 15 : Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum. Am J Physiol Gastrointest Liver Physiol2011; 300: G170. Google Scholar 16 : Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents. J Neurophysiol2008; 99: 244. Google Scholar 17 : Vigor of visceromotor response to urinary bladder distension in rats increases with repeated trials and stimulus intensity. Neurosci Lett2001; 22: 97. Google Scholar 18 : Reliable visceromotor responses are evoked by noxious bladder distension in mice. J Urol2004; 171: 1704. Link, Google Scholar 19 : Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways. Am J Physiol Gastrointest Liver Physiol2006; 290: G451. Google Scholar 20 : Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats. J Neurosci Res2008; 86: 2746. Google Scholar 21 : Cross-talk and sensitization of bladder afferent nerves. Neurourol Urodyn2010; 29: 77. Google Scholar 22 : Cystitis increases colorectal afferent sensitivity in the mouse. Am J Physiol Gastrointest Liver Physiol2009; 297: G1250. Google Scholar 23 : Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol2010; 225: 262. Google Scholar 24 : Dorsal root potentials and dorsal root reflexes: a double-edged sword. Exp Brain Res1999; 124: 395. Google Scholar 25 : Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. Am J Physiol Renal Physiol2006; 290: F1478. Google Scholar 26 : The same dorsal root ganglion neurons innervate uterus and colon in the rat. Neuroreport2007; 18: 209. Google Scholar 27 : Cross-organ sensitization of thoracic spinal neurons receiving noxious cardiac input in rats with gastroesophageal reflux. Am J Physiol Gastrointest Liver Physiol2010; 296: G934. Google Scholar 28 : Distribution of convergent afferents innervating bladder and prostate at dorsal root ganglia in rats. Urology2010; 76: 764e1. Google Scholar 29 : Convergence of bladder and colon sensory innervation occurs at the primary afferent level. Pain2007; 128: 235. Google Scholar 30 : Somatic and visceral primary afferents in the lower thoracic dorsal root ganglia of the cat. J Comp Neurol1984; 228: 422. Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAndersson K (2018) This Month in Investigative UrologyJournal of Urology, VOL. 196, NO. 3, (635-636), Online publication date: 1-Sep-2016. Volume 196Issue 3September 2016Page: 892-901 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordsvisceral afferentsprostatitisbladderpainprostateAcknowledgmentsMichael Burcham prepared the figures.MetricsAuthor Information Erica S. Schwartz More articles by this author Jun-Ho La More articles by this author Erin E. Young More articles by this author Bin Feng More articles by this author Sonali Joyce More articles by this author G.F. Gebhart More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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