FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302407022> ?p ?o ?g. }

• W2302407022 endingPage "20980" @default.
• W2302407022 startingPage "20966" @default.
• W2302407022 abstract "// Xinxin Si 1, 5, * , Yue Liu 1, 5, * , Jinghuan Lv 6 , Haijian Ding 1, 5 , Xin A. Zhang 4 , Lipei Shao 1, 5 , Nan Yang 1 , He Cheng 1, 5 , Luan Sun 1, 5 , Dongliang Zhu 5 , Yin Yang 1, 5 , Andi Li 1, 5 , Xiao Han 1 , Yujie Sun 1, 2, 3, 5 1 Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China 2 Collaborative Innovation Center for Cancer Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University, Nanjing, Jiangsu, China 3 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China 4 Department of Physiology and Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA 5 Department of Cell Biology, Nanjing Medical University, Nanjing, Jiangsu, China 6 Department of Pathology, Municipal Hospital, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu, China * These authors have contributed equally to this work Correspondence to: Yujie Sun, e-mail: yujiesun@njmu.edu.cn Keywords: ERα, DNMT1, DNMT3b, global DNA hypermethylation, breast cancer chemoresistance Received: July 31, 2015     Accepted: February 16, 2016     Published: March 12, 2016 ABSTRACT Drug-induced aberrant DNA methylation is the first identified epigenetic marker involved in chemotherapy resistance. Understanding how the aberrant DNA methylation is acquired would impact cancer treatment in theory and practice. In this study we systematically investigated whether and how ERα propelled aberrant global DNA hypermethylation in the context of breast cancer drug resistance. Our data demonstrated that anticancer drug paclitaxel (PTX) augmented ERα binding to the DNMT1 and DNMT3b promoters to activate DNMT1 and DNMT3b genes, enhancing the PTX resistance of breast cancer cells. In support of these observations, estrogen enhanced multi-drug resistance of breast cancer cells by up-regulation of DNMT1 and DNMT3b genes. Nevertheless, the aberrant global DNA hypermethylation was dominantly induced by ERα-activated-DNMT1, since DNMT1 over-expression significantly increased global DNA methylation and DNMT1 knockdown reversed the ERα-induced global DNA methylation. Altering DNMT3b expression had no detectable effect on global DNA methylation. Consistently, the expression level of DNMT1 was positively correlated with ERα in 78 breast cancer tissue samples shown by our immunohistochemistry (IHC) analysis and negatively correlated with relapse-free survival (RFS) and distance metastasis-free survival (DMFS) of ERα-positive breast cancer patients. This study provides a new perspective for understanding the mechanism underlying drug-resistance-facilitating aberrant DNA methylation in breast cancer and other estrogen dependent tumors." @default.
• W2302407022 created "2016-06-24" @default.
• W2302407022 creator A5001573736 @default.
• W2302407022 creator A5001937247 @default.
• W2302407022 creator A5005084111 @default.
• W2302407022 creator A5008473333 @default.
• W2302407022 creator A5016473420 @default.
• W2302407022 creator A5017081696 @default.
• W2302407022 creator A5018730551 @default.
• W2302407022 creator A5024707744 @default.
• W2302407022 creator A5030472799 @default.
• W2302407022 creator A5048254486 @default.
• W2302407022 creator A5056155560 @default.
• W2302407022 creator A5056191163 @default.
• W2302407022 creator A5061570552 @default.
• W2302407022 creator A5090351875 @default.
• W2302407022 date "2016-03-12" @default.
• W2302407022 modified "2023-10-18" @default.
• W2302407022 title "ERα propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells" @default.
• W2302407022 cites W1963567995 @default.
• W2302407022 cites W1967222077 @default.
• W2302407022 cites W1983307705 @default.
• W2302407022 cites W1985292554 @default.
• W2302407022 cites W1986731085 @default.
• W2302407022 cites W1995859582 @default.
• W2302407022 cites W2002519450 @default.
• W2302407022 cites W2006768012 @default.
• W2302407022 cites W2006934296 @default.
• W2302407022 cites W2016851204 @default.
• W2302407022 cites W2017984812 @default.
• W2302407022 cites W2025241935 @default.
• W2302407022 cites W2026986078 @default.
• W2302407022 cites W2028076974 @default.
• W2302407022 cites W2041515612 @default.
• W2302407022 cites W2057733872 @default.
• W2302407022 cites W2071221756 @default.
• W2302407022 cites W2077744460 @default.
• W2302407022 cites W2080620002 @default.
• W2302407022 cites W2083687033 @default.
• W2302407022 cites W2094815969 @default.
• W2302407022 cites W2096330673 @default.
• W2302407022 cites W2100773081 @default.
• W2302407022 cites W2103115795 @default.
• W2302407022 cites W2124418078 @default.
• W2302407022 cites W2137547257 @default.
• W2302407022 cites W2144021036 @default.
• W2302407022 cites W2144027697 @default.
• W2302407022 cites W2146613525 @default.
• W2302407022 cites W2148073949 @default.
• W2302407022 cites W2154419931 @default.
• W2302407022 cites W2158630016 @default.
• W2302407022 cites W2158717003 @default.
• W2302407022 cites W2163999275 @default.
• W2302407022 cites W4254951528 @default.
• W2302407022 doi "https://doi.org/10.18632/oncotarget.8038" @default.
• W2302407022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4991505" @default.
• W2302407022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26980709" @default.
• W2302407022 hasPublicationYear "2016" @default.
• W2302407022 type Work @default.
• W2302407022 sameAs 2302407022 @default.
• W2302407022 citedByCount "16" @default.
• W2302407022 countsByYear W23024070222016 @default.
• W2302407022 countsByYear W23024070222017 @default.
• W2302407022 countsByYear W23024070222018 @default.
• W2302407022 countsByYear W23024070222019 @default.
• W2302407022 countsByYear W23024070222021 @default.
• W2302407022 countsByYear W23024070222022 @default.
• W2302407022 countsByYear W23024070222023 @default.
• W2302407022 crossrefType "journal-article" @default.
• W2302407022 hasAuthorship W2302407022A5001573736 @default.
• W2302407022 hasAuthorship W2302407022A5001937247 @default.
• W2302407022 hasAuthorship W2302407022A5005084111 @default.
• W2302407022 hasAuthorship W2302407022A5008473333 @default.
• W2302407022 hasAuthorship W2302407022A5016473420 @default.
• W2302407022 hasAuthorship W2302407022A5017081696 @default.
• W2302407022 hasAuthorship W2302407022A5018730551 @default.
• W2302407022 hasAuthorship W2302407022A5024707744 @default.
• W2302407022 hasAuthorship W2302407022A5030472799 @default.
• W2302407022 hasAuthorship W2302407022A5048254486 @default.
• W2302407022 hasAuthorship W2302407022A5056155560 @default.
• W2302407022 hasAuthorship W2302407022A5056191163 @default.
• W2302407022 hasAuthorship W2302407022A5061570552 @default.
• W2302407022 hasAuthorship W2302407022A5090351875 @default.
• W2302407022 hasBestOaLocation W23024070221 @default.
• W2302407022 hasConcept C104317684 @default.
• W2302407022 hasConcept C114851261 @default.
• W2302407022 hasConcept C121608353 @default.
• W2302407022 hasConcept C126322002 @default.
• W2302407022 hasConcept C143998085 @default.
• W2302407022 hasConcept C150194340 @default.
• W2302407022 hasConcept C151730666 @default.
• W2302407022 hasConcept C175211621 @default.
• W2302407022 hasConcept C17744445 @default.
• W2302407022 hasConcept C190727270 @default.
• W2302407022 hasConcept C191935318 @default.
• W2302407022 hasConcept C199539241 @default.
• W2302407022 hasConcept C2779343474 @default.
• W2302407022 hasConcept C41091548 @default.

• next