Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302459651> ?p ?o ?g. }
- W2302459651 endingPage "138" @default.
- W2302459651 startingPage "127" @default.
- W2302459651 abstract "In mammals, the toll-like receptors (TLRs) play a major role in initiating innate immune responses against pathogens. Comparison of the TLRs in different mammals may help in understanding the TLR-mediated responses and developing of animal models and efficient therapeutic measures for infectious diseases. The Chinese tree shrew (Tupaia belangeri chinensis), a small mammal with a close relationship to primates, is a viable experimental animal for studying viral and bacterial infections. In this study, we characterized the TLRs genes (tTLRs) in the Chinese tree shrew and identified 13 putative TLRs, which are orthologs of mammalian TLR1-TLR9 and TLR11-TLR13, and TLR10 was a pseudogene in tree shrew. Positive selection analyses using the Maximum likelihood (ML) method showed that tTLR8 and tTLR9 were under positive selection, which might be associated with the adaptation to the pathogen challenge. The mRNA expression levels of tTLRs presented an overall low and tissue-specific pattern, and were significantly upregulated upon Hepatitis C virus (HCV) infection. tTLR4 and tTLR9 underwent alternative splicing, which leads to different transcripts. Phylogenetic analysis and TLR structure prediction indicated that tTLRs were evolutionarily conserved, which might reflect an ancient mechanism and structure in the innate immune response system. Taken together, TLRs had both conserved and unique features in the Chinese tree shrew." @default.
- W2302459651 created "2016-06-24" @default.
- W2302459651 creator A5003060951 @default.
- W2302459651 creator A5003365817 @default.
- W2302459651 creator A5026441951 @default.
- W2302459651 creator A5049440121 @default.
- W2302459651 creator A5053133948 @default.
- W2302459651 creator A5059087104 @default.
- W2302459651 creator A5066652935 @default.
- W2302459651 date "2016-07-01" @default.
- W2302459651 modified "2023-09-24" @default.
- W2302459651 title "Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)" @default.
- W2302459651 cites W1514955262 @default.
- W2302459651 cites W1655860314 @default.
- W2302459651 cites W1962077068 @default.
- W2302459651 cites W1968693613 @default.
- W2302459651 cites W1969072247 @default.
- W2302459651 cites W1972140057 @default.
- W2302459651 cites W1972503143 @default.
- W2302459651 cites W1977922844 @default.
- W2302459651 cites W1977999392 @default.
- W2302459651 cites W1980926556 @default.
- W2302459651 cites W1982337542 @default.
- W2302459651 cites W1984093225 @default.
- W2302459651 cites W1987617154 @default.
- W2302459651 cites W1992645970 @default.
- W2302459651 cites W1995744610 @default.
- W2302459651 cites W1999452347 @default.
- W2302459651 cites W2004622806 @default.
- W2302459651 cites W2004773897 @default.
- W2302459651 cites W2008353059 @default.
- W2302459651 cites W2013469022 @default.
- W2302459651 cites W2022745948 @default.
- W2302459651 cites W2027052155 @default.
- W2302459651 cites W2028584099 @default.
- W2302459651 cites W2034533794 @default.
- W2302459651 cites W2035545442 @default.
- W2302459651 cites W2047682311 @default.
- W2302459651 cites W2047986499 @default.
- W2302459651 cites W2049115723 @default.
- W2302459651 cites W2053246453 @default.
- W2302459651 cites W2056187570 @default.
- W2302459651 cites W2062267695 @default.
- W2302459651 cites W2062536838 @default.
- W2302459651 cites W2067359484 @default.
- W2302459651 cites W2067806955 @default.
- W2302459651 cites W2068933786 @default.
- W2302459651 cites W2069981713 @default.
- W2302459651 cites W2073737981 @default.
- W2302459651 cites W2075295096 @default.
- W2302459651 cites W2082476225 @default.
- W2302459651 cites W2089171422 @default.
- W2302459651 cites W2093029664 @default.
- W2302459651 cites W2097260296 @default.
- W2302459651 cites W2097977090 @default.
- W2302459651 cites W2098821127 @default.
- W2302459651 cites W2100439192 @default.
- W2302459651 cites W2101363646 @default.
- W2302459651 cites W2101671848 @default.
- W2302459651 cites W2102794755 @default.
- W2302459651 cites W2103414463 @default.
- W2302459651 cites W2103776714 @default.
- W2302459651 cites W2103931357 @default.
- W2302459651 cites W2105134766 @default.
- W2302459651 cites W2109491705 @default.
- W2302459651 cites W2110335151 @default.
- W2302459651 cites W2111260918 @default.
- W2302459651 cites W2111466507 @default.
- W2302459651 cites W2122011276 @default.
- W2302459651 cites W2125027923 @default.
- W2302459651 cites W2126829776 @default.
- W2302459651 cites W2127060044 @default.
- W2302459651 cites W2129961630 @default.
- W2302459651 cites W2132926880 @default.
- W2302459651 cites W2133449490 @default.
- W2302459651 cites W2133941567 @default.
- W2302459651 cites W2134505828 @default.
- W2302459651 cites W2138049915 @default.
- W2302459651 cites W2138811813 @default.
- W2302459651 cites W2138860727 @default.
- W2302459651 cites W2138870543 @default.
- W2302459651 cites W2141052558 @default.
- W2302459651 cites W2142214679 @default.
- W2302459651 cites W2142563401 @default.
- W2302459651 cites W2148159716 @default.
- W2302459651 cites W2152207030 @default.
- W2302459651 cites W2158789461 @default.
- W2302459651 cites W2161078046 @default.
- W2302459651 cites W2170565120 @default.
- W2302459651 cites W2208719684 @default.
- W2302459651 cites W2256756668 @default.
- W2302459651 cites W2316426774 @default.
- W2302459651 cites W2316715888 @default.
- W2302459651 cites W2390453790 @default.
- W2302459651 cites W653008055 @default.
- W2302459651 cites W82564890 @default.
- W2302459651 doi "https://doi.org/10.1016/j.dci.2016.02.025" @default.
- W2302459651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26923770" @default.