FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302483310> ?p ?o ?g. }

• W2302483310 endingPage "244" @default.
• W2302483310 startingPage "233" @default.
• W2302483310 abstract "<b><i>Background:</i></b> In vitro studies suggest that antimicrobial activity of antibiotics meant to treat central nervous system infections such as meningitis or ventriculitis may be altered by cerebrospinal fluid (CSF). This could explain the reason behind the often observed discrepancies between the activity of antibiotics determined in artificial growth media in vitro, and their sometimes reduced clinical efficacy in CSF in vivo. If conducted in CSF, in vitro microbiological investigations might predict the ability of antibiotic drugs to treat CSF infections better than experiments in artificial growth media. In addition, they are less expensive, critical and time consuming than animal studies, and might potentially be appreciated in drug development as a rapid and cost-effective means to gain valuable information on drugs meant to treat infections residing in CSF. <b><i>Summary:</i></b> Data from microbiological in vitro experiments performed in CSF were compiled for fosfomycin, rifampicin, cefepime, cefotaxime, ceftriaxone, ciprofloxacin, gentamicin and vancomycin. Where possible, correlations between in vitro data and evidence from in vivo studies were established. <b><i>Key Messages:</i></b> As discussed in the text, no clear correlations between in vitro studies in CSF and clinical outcomes could be identified. Methodological recommendations derived from the collected studies are summarized in order to optimize future research on the topic." @default.
• W2302483310 created "2016-06-24" @default.
• W2302483310 creator A5042620178 @default.
• W2302483310 creator A5055760424 @default.
• W2302483310 creator A5081667950 @default.
• W2302483310 creator A5089417888 @default.
• W2302483310 date "2016-01-01" @default.
• W2302483310 modified "2023-10-13" @default.
• W2302483310 title "Understanding the Activity of Antibiotics in Cerebrospinal Fluid in vitro" @default.
• W2302483310 cites W166175985 @default.
• W2302483310 cites W1965126158 @default.
• W2302483310 cites W1965725897 @default.
• W2302483310 cites W1966138471 @default.
• W2302483310 cites W1977371637 @default.
• W2302483310 cites W1986809510 @default.
• W2302483310 cites W1995447535 @default.
• W2302483310 cites W2000797563 @default.
• W2302483310 cites W2001506634 @default.
• W2302483310 cites W2013186536 @default.
• W2302483310 cites W2022229601 @default.
• W2302483310 cites W2024722216 @default.
• W2302483310 cites W2031465545 @default.
• W2302483310 cites W2035642879 @default.
• W2302483310 cites W2035995251 @default.
• W2302483310 cites W2038080602 @default.
• W2302483310 cites W2048188459 @default.
• W2302483310 cites W2052477381 @default.
• W2302483310 cites W2059836793 @default.
• W2302483310 cites W2066830532 @default.
• W2302483310 cites W2071856623 @default.
• W2302483310 cites W2075065502 @default.
• W2302483310 cites W2075304164 @default.
• W2302483310 cites W2079000326 @default.
• W2302483310 cites W2080025974 @default.
• W2302483310 cites W2087976728 @default.
• W2302483310 cites W2089091692 @default.
• W2302483310 cites W2102765259 @default.
• W2302483310 cites W2106868673 @default.
• W2302483310 cites W2111321389 @default.
• W2302483310 cites W2115249197 @default.
• W2302483310 cites W2119237294 @default.
• W2302483310 cites W2119553889 @default.
• W2302483310 cites W2120614544 @default.
• W2302483310 cites W2125523016 @default.
• W2302483310 cites W2127182132 @default.
• W2302483310 cites W2129085875 @default.
• W2302483310 cites W2129441585 @default.
• W2302483310 cites W2136942615 @default.
• W2302483310 cites W2144299128 @default.
• W2302483310 cites W2145056323 @default.
• W2302483310 cites W2146693292 @default.
• W2302483310 cites W2156642613 @default.
• W2302483310 cites W2163725776 @default.
• W2302483310 cites W2166938118 @default.
• W2302483310 cites W2167768564 @default.
• W2302483310 cites W2170382400 @default.
• W2302483310 cites W2172185965 @default.
• W2302483310 cites W2468442095 @default.
• W2302483310 cites W37054057 @default.
• W2302483310 cites W4217816 @default.
• W2302483310 cites W94144281 @default.
• W2302483310 cites W2564646858 @default.
• W2302483310 doi "https://doi.org/10.1159/000444263" @default.
• W2302483310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26881776" @default.
• W2302483310 hasPublicationYear "2016" @default.
• W2302483310 type Work @default.
• W2302483310 sameAs 2302483310 @default.
• W2302483310 citedByCount "11" @default.
• W2302483310 countsByYear W23024833102017 @default.
• W2302483310 countsByYear W23024833102019 @default.
• W2302483310 countsByYear W23024833102020 @default.
• W2302483310 countsByYear W23024833102021 @default.
• W2302483310 countsByYear W23024833102022 @default.
• W2302483310 countsByYear W23024833102023 @default.
• W2302483310 crossrefType "journal-article" @default.
• W2302483310 hasAuthorship W2302483310A5042620178 @default.
• W2302483310 hasAuthorship W2302483310A5055760424 @default.
• W2302483310 hasAuthorship W2302483310A5081667950 @default.
• W2302483310 hasAuthorship W2302483310A5089417888 @default.
• W2302483310 hasBestOaLocation W23024833101 @default.
• W2302483310 hasConcept C126322002 @default.
• W2302483310 hasConcept C141071460 @default.
• W2302483310 hasConcept C150903083 @default.
• W2302483310 hasConcept C202751555 @default.
• W2302483310 hasConcept C207001950 @default.
• W2302483310 hasConcept C2775832221 @default.
• W2302483310 hasConcept C2778512257 @default.
• W2302483310 hasConcept C2778719061 @default.
• W2302483310 hasConcept C2778980435 @default.
• W2302483310 hasConcept C2779489039 @default.
• W2302483310 hasConcept C2779651940 @default.
• W2302483310 hasConcept C2779862588 @default.
• W2302483310 hasConcept C2781026528 @default.
• W2302483310 hasConcept C4937899 @default.
• W2302483310 hasConcept C501593827 @default.
• W2302483310 hasConcept C523546767 @default.
• W2302483310 hasConcept C54355233 @default.
• W2302483310 hasConcept C55493867 @default.

• next