Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302503876> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2302503876 abstract "Hemorrhagic hypotension produces significantly increased plasma arginine vasopression (AVP) concentrations. We have utilized a specific antagonist (AVP-A) of the pressor effects of endogenous AVP to investigate the role of this neurohypophyseal hormone on the pathogenesis of hemorrhagic shock. Infusion of the AVP-A (2 micrograms/kg bolus + 2 micrograms X kg-1 X h-1 infusion) into sham-shocked animals produced no significant changes in any of the observed experimental variables. Cats subjected to hemorrhagic shock given AVP-A had final superior mesenteric artery flow (SMAF) values significantly (P less than 0.05) higher than shock cats given vehicle (7.7 +/- 1.1 vs. 4.5 +/- 0.8 ml X kg-1 X min-1, respectively). Increases in postreinfusion plasma cathepsin D activities were significantly blunted in hemorrhaged animals treated with AVP-A (10.4 +/- 2.0 vs. 24.8 +/- 5.5 U/mg protein; P less than 0.05). Plasma proteolysis as well as the plasma accumulation of myocardial depressant factor (MDF) were also significantly modulated by AVP-A treatment in hemorrhaged animals. MDF activities were 75 +/- 6 and 53 +/- 4 U/ml (P less than 0.02) for shock cats given vehicle or AVP-A, respectively. However, these beneficial actions were not reflected in any significant improvement in postreinfusion mean arterial blood pressure (MABP). These findings suggest that endogenous AVP functions not only as a potent splanchnic vasoconstrictor but also as a key humoral factor in the maintenance of postreinfusion MABP, a profile that is different from the role of angiotensin II, the other major splanchnic vasoconstrictor, in shock." @default.
- W2302503876 created "2016-06-24" @default.
- W2302503876 creator A5030660449 @default.
- W2302503876 creator A5040162739 @default.
- W2302503876 creator A5049168798 @default.
- W2302503876 date "1984-02-01" @default.
- W2302503876 modified "2023-10-17" @default.
- W2302503876 title "Role of AVP in maintenance of circulatory homeostasis during hemorrhagic shock" @default.
- W2302503876 doi "https://doi.org/10.1152/ajpheart.1984.246.2.h174" @default.
- W2302503876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6696129" @default.
- W2302503876 hasPublicationYear "1984" @default.
- W2302503876 type Work @default.
- W2302503876 sameAs 2302503876 @default.
- W2302503876 citedByCount "6" @default.
- W2302503876 crossrefType "journal-article" @default.
- W2302503876 hasAuthorship W2302503876A5030660449 @default.
- W2302503876 hasAuthorship W2302503876A5040162739 @default.
- W2302503876 hasAuthorship W2302503876A5049168798 @default.
- W2302503876 hasConcept C126322002 @default.
- W2302503876 hasConcept C134018914 @default.
- W2302503876 hasConcept C16613235 @default.
- W2302503876 hasConcept C178853913 @default.
- W2302503876 hasConcept C2775849017 @default.
- W2302503876 hasConcept C2776370428 @default.
- W2302503876 hasConcept C2779904517 @default.
- W2302503876 hasConcept C2780799893 @default.
- W2302503876 hasConcept C2781300812 @default.
- W2302503876 hasConcept C2908929049 @default.
- W2302503876 hasConcept C43376680 @default.
- W2302503876 hasConcept C63645605 @default.
- W2302503876 hasConcept C71924100 @default.
- W2302503876 hasConcept C72859922 @default.
- W2302503876 hasConcept C84393581 @default.
- W2302503876 hasConceptScore W2302503876C126322002 @default.
- W2302503876 hasConceptScore W2302503876C134018914 @default.
- W2302503876 hasConceptScore W2302503876C16613235 @default.
- W2302503876 hasConceptScore W2302503876C178853913 @default.
- W2302503876 hasConceptScore W2302503876C2775849017 @default.
- W2302503876 hasConceptScore W2302503876C2776370428 @default.
- W2302503876 hasConceptScore W2302503876C2779904517 @default.
- W2302503876 hasConceptScore W2302503876C2780799893 @default.
- W2302503876 hasConceptScore W2302503876C2781300812 @default.
- W2302503876 hasConceptScore W2302503876C2908929049 @default.
- W2302503876 hasConceptScore W2302503876C43376680 @default.
- W2302503876 hasConceptScore W2302503876C63645605 @default.
- W2302503876 hasConceptScore W2302503876C71924100 @default.
- W2302503876 hasConceptScore W2302503876C72859922 @default.
- W2302503876 hasConceptScore W2302503876C84393581 @default.
- W2302503876 hasLocation W23025038761 @default.
- W2302503876 hasLocation W23025038762 @default.
- W2302503876 hasOpenAccess W2302503876 @default.
- W2302503876 hasPrimaryLocation W23025038761 @default.
- W2302503876 hasRelatedWork W2002164469 @default.
- W2302503876 hasRelatedWork W2015579912 @default.
- W2302503876 hasRelatedWork W2027431676 @default.
- W2302503876 hasRelatedWork W2047925791 @default.
- W2302503876 hasRelatedWork W2057294511 @default.
- W2302503876 hasRelatedWork W2070539845 @default.
- W2302503876 hasRelatedWork W2119874115 @default.
- W2302503876 hasRelatedWork W2302503876 @default.
- W2302503876 hasRelatedWork W2569510797 @default.
- W2302503876 hasRelatedWork W83076824 @default.
- W2302503876 isParatext "false" @default.
- W2302503876 isRetracted "false" @default.
- W2302503876 magId "2302503876" @default.
- W2302503876 workType "article" @default.