FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302635387> ?p ?o ?g. }

• W2302635387 abstract "Antiangiogenic properties of thalidomide have created an interest in the use of the drug in treatment of cancer. However, thalidomide is responsible for thalidomide embryopathy (TE). A lack of knowledge regarding the mechanisms of thalidomide teratogenesis acts as a barrier in the aim to synthesize a safer analogue of thalidomide. Recently, our group detected a higher frequency of alleles that impair the pro-angiogenic mechanisms of endothelial nitric oxide synthase (eNOS), coded by the NOS3 gene. In this study we evaluated variable number tandem repeats (VNTR) functional polymorphism in intron 4 of NOS3 in individuals with TE (38) and Brazilians without congenital anomalies (136). Haplotypes were estimated for this VNTR with previously analyzed polymorphisms, rs2070744 (-786C > T) and rs1799983 (894T > G), in promoter region and exon 7, respectively. Haplotypic distribution was different between the groups (p = 0.007). Alleles -786C (rs2070744) and 4b (VNTR), associated with decreased NOS3 expression, presented in higher frequency in TE individuals (p = 0.018; OR = 2.57; IC = 1.2-5.8). This association was not identified with polymorphism 894T > G (p = 0.079), which influences eNOS enzymatic activity. These results suggest variants in NOS3, with pre-transcriptional effects as susceptibility factors, influencing the risk TE development. This finding generates insight for a new approach to research that pursues a safer analogue." @default.
• W2302635387 created "2016-06-24" @default.
• W2302635387 creator A5020218271 @default.
• W2302635387 creator A5021788092 @default.
• W2302635387 creator A5021802786 @default.
• W2302635387 creator A5031469188 @default.
• W2302635387 creator A5033125558 @default.
• W2302635387 creator A5045371414 @default.
• W2302635387 creator A5048997279 @default.
• W2302635387 date "2016-03-23" @default.
• W2302635387 modified "2023-09-30" @default.
• W2302635387 title "New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors" @default.
• W2302635387 cites W1519102962 @default.
• W2302635387 cites W1545043206 @default.
• W2302635387 cites W1781455635 @default.
• W2302635387 cites W1887682009 @default.
• W2302635387 cites W1964591237 @default.
• W2302635387 cites W1964750695 @default.
• W2302635387 cites W1967815233 @default.
• W2302635387 cites W1987072267 @default.
• W2302635387 cites W1989310986 @default.
• W2302635387 cites W1991812881 @default.
• W2302635387 cites W1996028731 @default.
• W2302635387 cites W2003113207 @default.
• W2302635387 cites W2005505584 @default.
• W2302635387 cites W2005548436 @default.
• W2302635387 cites W2015941287 @default.
• W2302635387 cites W2026644936 @default.
• W2302635387 cites W2028435774 @default.
• W2302635387 cites W2036473942 @default.
• W2302635387 cites W2045012731 @default.
• W2302635387 cites W2075761743 @default.
• W2302635387 cites W2076795933 @default.
• W2302635387 cites W2077229049 @default.
• W2302635387 cites W2077507399 @default.
• W2302635387 cites W2089764333 @default.
• W2302635387 cites W2089781472 @default.
• W2302635387 cites W2096791516 @default.
• W2302635387 cites W2100286113 @default.
• W2302635387 cites W2108923962 @default.
• W2302635387 cites W2117872775 @default.
• W2302635387 cites W2142031342 @default.
• W2302635387 cites W2144024299 @default.
• W2302635387 cites W2144198949 @default.
• W2302635387 cites W2145570729 @default.
• W2302635387 cites W2147061562 @default.
• W2302635387 cites W2162559503 @default.
• W2302635387 cites W2163445917 @default.
• W2302635387 cites W2165881188 @default.
• W2302635387 cites W2320209117 @default.
• W2302635387 cites W2332093419 @default.
• W2302635387 cites W34703202 @default.
• W2302635387 cites W4237160604 @default.
• W2302635387 cites W4255624333 @default.
• W2302635387 doi "https://doi.org/10.1038/srep23404" @default.
• W2302635387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4804217" @default.
• W2302635387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27004986" @default.
• W2302635387 hasPublicationYear "2016" @default.
• W2302635387 type Work @default.
• W2302635387 sameAs 2302635387 @default.
• W2302635387 citedByCount "12" @default.
• W2302635387 countsByYear W23026353872016 @default.
• W2302635387 countsByYear W23026353872017 @default.
• W2302635387 countsByYear W23026353872019 @default.
• W2302635387 countsByYear W23026353872020 @default.
• W2302635387 countsByYear W23026353872021 @default.
• W2302635387 countsByYear W23026353872022 @default.
• W2302635387 crossrefType "journal-article" @default.
• W2302635387 hasAuthorship W2302635387A5020218271 @default.
• W2302635387 hasAuthorship W2302635387A5021788092 @default.
• W2302635387 hasAuthorship W2302635387A5021802786 @default.
• W2302635387 hasAuthorship W2302635387A5031469188 @default.
• W2302635387 hasAuthorship W2302635387A5033125558 @default.
• W2302635387 hasAuthorship W2302635387A5045371414 @default.
• W2302635387 hasAuthorship W2302635387A5048997279 @default.
• W2302635387 hasBestOaLocation W23026353871 @default.
• W2302635387 hasConcept C104317684 @default.
• W2302635387 hasConcept C126322002 @default.
• W2302635387 hasConcept C180754005 @default.
• W2302635387 hasConcept C189036908 @default.
• W2302635387 hasConcept C197754878 @default.
• W2302635387 hasConcept C2776364478 @default.
• W2302635387 hasConcept C2777622882 @default.
• W2302635387 hasConcept C2778326061 @default.
• W2302635387 hasConcept C2779609412 @default.
• W2302635387 hasConcept C2779698670 @default.
• W2302635387 hasConcept C36823959 @default.
• W2302635387 hasConcept C37463918 @default.
• W2302635387 hasConcept C519581460 @default.
• W2302635387 hasConcept C54355233 @default.
• W2302635387 hasConcept C71924100 @default.
• W2302635387 hasConcept C86803240 @default.
• W2302635387 hasConcept C94671646 @default.
• W2302635387 hasConceptScore W2302635387C104317684 @default.
• W2302635387 hasConceptScore W2302635387C126322002 @default.
• W2302635387 hasConceptScore W2302635387C180754005 @default.
• W2302635387 hasConceptScore W2302635387C189036908 @default.
• W2302635387 hasConceptScore W2302635387C197754878 @default.
• W2302635387 hasConceptScore W2302635387C2776364478 @default.
• W2302635387 hasConceptScore W2302635387C2777622882 @default.

• next