Matches in SemOpenAlex for { <https://semopenalex.org/work/W2302745330> ?p ?o ?g. }
- W2302745330 endingPage "158" @default.
- W2302745330 startingPage "152" @default.
- W2302745330 abstract "Molecular investigation of breast tumors has permitted better understanding about interaction of genes and pathways involved in tumor progression.The aim of this study was to evaluate the association between genes belonging to the pathway of apoptosis with tumor response to photodynamic therapy.The mammary tumors were induced in twenty-four Spraguey-Dawley female rats by oral gavage of 7,12-dimethylbenz(a)anthracene (8mg/Kg body weight). Animals were divided into three groups: G1 (normal tissue), G2 (tumors without treatment), G3 (animals euthanized 48h after treatment). The photosensitizer used was a chlorin, 5,15-bis-(2-bromo-5-hydroxyphenyl) chlorin in the dose of 8mg/kg for each animal. Light source of diode laser at a wavelength of 660nm, fluence rate of 100mW/cm, and light dose of 100J/cm was delivery to lesions for treatment. A sample from each animal was investigated by quantitative real time PCR using Rat Apoptosis RT(2) Profiler™ PCR Array platform.Pro-apoptotic BAK1, CARD6, CASP8, CIDEA, CIDEB, DAPK1, TNF, TNFRSF10B, FASLG, LOC687813, and TP73 genes showed increased expression, and CD40 anti-apoptotic gene showed decreased expression in the group who underwent PDT (G3) in relation to G2.The results indicated that these genes are involved more directly with cellular apoptosis induced by PDT using the Chlorin photosensitizer." @default.
- W2302745330 created "2016-06-24" @default.
- W2302745330 creator A5011123686 @default.
- W2302745330 creator A5015327663 @default.
- W2302745330 creator A5026062694 @default.
- W2302745330 creator A5041061300 @default.
- W2302745330 creator A5048173098 @default.
- W2302745330 creator A5085651858 @default.
- W2302745330 creator A5090298673 @default.
- W2302745330 date "2016-06-01" @default.
- W2302745330 modified "2023-10-16" @default.
- W2302745330 title "Molecular analysis of apoptosis pathway after photodynamic therapy in breast cancer: Animal model study" @default.
- W2302745330 cites W1509251686 @default.
- W2302745330 cites W1558646058 @default.
- W2302745330 cites W1583006772 @default.
- W2302745330 cites W1799955757 @default.
- W2302745330 cites W1916661321 @default.
- W2302745330 cites W1977386771 @default.
- W2302745330 cites W1977792178 @default.
- W2302745330 cites W1978556859 @default.
- W2302745330 cites W1987396009 @default.
- W2302745330 cites W1989062380 @default.
- W2302745330 cites W1991154912 @default.
- W2302745330 cites W1992270424 @default.
- W2302745330 cites W1993118551 @default.
- W2302745330 cites W1995406107 @default.
- W2302745330 cites W1996813579 @default.
- W2302745330 cites W2004457956 @default.
- W2302745330 cites W2006117179 @default.
- W2302745330 cites W2007681987 @default.
- W2302745330 cites W2011524144 @default.
- W2302745330 cites W2013326233 @default.
- W2302745330 cites W2021300711 @default.
- W2302745330 cites W2028305534 @default.
- W2302745330 cites W2028526641 @default.
- W2302745330 cites W2032063521 @default.
- W2302745330 cites W2035611334 @default.
- W2302745330 cites W2036205949 @default.
- W2302745330 cites W2041352318 @default.
- W2302745330 cites W2046949873 @default.
- W2302745330 cites W2049226990 @default.
- W2302745330 cites W2053326267 @default.
- W2302745330 cites W2057871351 @default.
- W2302745330 cites W2059321345 @default.
- W2302745330 cites W2077628780 @default.
- W2302745330 cites W2078225696 @default.
- W2302745330 cites W2080458504 @default.
- W2302745330 cites W2081897799 @default.
- W2302745330 cites W2082651961 @default.
- W2302745330 cites W2088318957 @default.
- W2302745330 cites W2091210609 @default.
- W2302745330 cites W2093823051 @default.
- W2302745330 cites W2096680191 @default.
- W2302745330 cites W2104855170 @default.
- W2302745330 cites W2112943524 @default.
- W2302745330 cites W2114538819 @default.
- W2302745330 cites W2116629267 @default.
- W2302745330 cites W2119304949 @default.
- W2302745330 cites W2141216640 @default.
- W2302745330 cites W2141930618 @default.
- W2302745330 cites W2151734986 @default.
- W2302745330 cites W2159753961 @default.
- W2302745330 cites W2403155449 @default.
- W2302745330 doi "https://doi.org/10.1016/j.pdpdt.2016.03.006" @default.
- W2302745330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27018246" @default.
- W2302745330 hasPublicationYear "2016" @default.
- W2302745330 type Work @default.
- W2302745330 sameAs 2302745330 @default.
- W2302745330 citedByCount "8" @default.
- W2302745330 countsByYear W23027453302016 @default.
- W2302745330 countsByYear W23027453302017 @default.
- W2302745330 countsByYear W23027453302018 @default.
- W2302745330 countsByYear W23027453302020 @default.
- W2302745330 countsByYear W23027453302021 @default.
- W2302745330 crossrefType "journal-article" @default.
- W2302745330 hasAuthorship W2302745330A5011123686 @default.
- W2302745330 hasAuthorship W2302745330A5015327663 @default.
- W2302745330 hasAuthorship W2302745330A5026062694 @default.
- W2302745330 hasAuthorship W2302745330A5041061300 @default.
- W2302745330 hasAuthorship W2302745330A5048173098 @default.
- W2302745330 hasAuthorship W2302745330A5085651858 @default.
- W2302745330 hasAuthorship W2302745330A5090298673 @default.
- W2302745330 hasConcept C121608353 @default.
- W2302745330 hasConcept C126322002 @default.
- W2302745330 hasConcept C142724271 @default.
- W2302745330 hasConcept C178790620 @default.
- W2302745330 hasConcept C185592680 @default.
- W2302745330 hasConcept C190283241 @default.
- W2302745330 hasConcept C2781323092 @default.
- W2302745330 hasConcept C2781469039 @default.
- W2302745330 hasConcept C502942594 @default.
- W2302745330 hasConcept C55493867 @default.
- W2302745330 hasConcept C71924100 @default.
- W2302745330 hasConcept C75473681 @default.
- W2302745330 hasConcept C86803240 @default.
- W2302745330 hasConceptScore W2302745330C121608353 @default.
- W2302745330 hasConceptScore W2302745330C126322002 @default.
- W2302745330 hasConceptScore W2302745330C142724271 @default.