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• W2302777536 abstract "No AccessJournal of UrologyInvestigative Urology1 Sep 2016Bladder Distension Increases Blood Flow in Pain Related Brain Structures in Subjects with Interstitial Cystitis Georg Deutsch, Hrishikesh Deshpande, Michael A. Frölich, H. Henry Lai, and Timothy J. Ness Georg DeutschGeorg Deutsch Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author , Hrishikesh DeshpandeHrishikesh Deshpande Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author , Michael A. FrölichMichael A. Frölich Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author , H. Henry LaiH. Henry Lai Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri Financial interest and/or other relationship with Medtronic. More articles by this author , and Timothy J. NessTimothy J. Ness Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.03.135AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In healthy control subjects certain brain regions of interest demonstrate increased regional cerebral blood flow in response to painful stimuli. We examined the effect of bladder distension on arterial spin label functional magnetic resonance imaging measures of regional cerebral blood flow in regions of interest in subjects with interstitial cystitis. Materials and Methods: A total of 11 female subjects with interstitial cystitis and 11 healthy controls underwent 3 brain perfusion scan studies using arterial spin label functional magnetic resonance imaging, including 1) with a full bladder, 2) with an empty bladder and 3) while experiencing heat pain. Regional cerebral blood flow was calculated using custom software and individual scans were spatially normalized to the MNI (Montreal Neurological Institute) template. Region of interest based, absolute regional cerebral blood flow was determined for each condition and for the within group/within subject regional cerebral blood flow distribution changes induced by each condition. Results: Bladder distension was associated with robust increases in regional cerebral blood flow in subjects with interstitial cystitis. The increases were greater than those in healthy controls in multiple regions of interest, including the supplemental motor area (mainly Brodmann area 6), the motor and sensory cortex, the insula bilaterally, the hippocampal structures bilaterally, and the middle and posterior cingulate areas bilaterally. During heat pain healthy controls had more robust regional cerebral blood flow increases in the amygdala bilaterally. At baseline with an empty bladder there was lower regional cerebral blood flow in the insula, and the mid and posterior cingulate cortex bilaterally in subjects with interstitial cystitis. Conclusions: Compared to healthy controls, subjects with interstitial cystitis have limited differences in regional cerebral blood flow in baseline (empty bladder) conditions as well as during heat pain. However, they had robust regional cerebral blood flow increases in the full bladder state in regions of interest typically associated with pain, emotion and/or motor control, indicating altered processing of bladder related sensations. References 1 : Brain responses to changes in bladder volume and urge to void in healthy men. Brain2001; 124: 369. Google Scholar 2 : Brain activation during micturition in women. Brain1998; 121: 2033. Google Scholar 3 : Control of bladder sensations: an fMRI study of brain activity and effective connectivity. Neuroimage2009; 47: 18. 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Google Scholar 30 : Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: a MAPP Research Network neuroimaging study. Neuroimage Clin2015; 8: 493. Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 196Issue 3September 2016Page: 902-910 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordsbraincystitis, interstitialcerebrovascular circulationpainurinary bladderMetricsAuthor Information Georg Deutsch Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author Hrishikesh Deshpande Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author Michael A. Frölich Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author H. Henry Lai Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri Financial interest and/or other relationship with Medtronic. More articles by this author Timothy J. Ness Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2302777536 title "Bladder Distension Increases Blood Flow in Pain Related Brain Structures in Subjects with Interstitial Cystitis" @default.
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