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- W2302864647 abstract "LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genomes. Due to their high levels of sequence identity and the existence of many polymorphic insertions absent from the reference genome, the transcriptional activation of individual genomic L1HS-Ta copies remains poorly understood. Here we comprehensively mapped fixed and polymorphic L1HS-Ta copies in 12 commonly-used somatic cell lines, and identified transcriptional and epigenetic signatures allowing the unambiguous identification of active L1HS-Ta copies in their genomic context. Strikingly, only a very restricted subset of L1HS-Ta loci - some being polymorphic among individuals - significantly contributes to the bulk of L1 expression, and these loci are differentially regulated among distinct cell lines. Thus, our data support a local model of L1 transcriptional activation in somatic cells, governed by individual-, locus-, and cell-type-specific determinants." @default.
- W2302864647 created "2016-06-24" @default.
- W2302864647 creator A5014877984 @default.
- W2302864647 creator A5016607425 @default.
- W2302864647 creator A5028480629 @default.
- W2302864647 creator A5053235206 @default.
- W2302864647 creator A5058288998 @default.
- W2302864647 creator A5067871616 @default.
- W2302864647 creator A5069220675 @default.
- W2302864647 creator A5070632637 @default.
- W2302864647 creator A5070946467 @default.
- W2302864647 date "2016-03-26" @default.
- W2302864647 modified "2023-10-18" @default.
- W2302864647 title "Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci" @default.
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