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- W2302888901 abstract "A new and accurate chiral liquid chromatographic method was developed for the enantiomeric resolution of Dapoxetine hydrochloride, (S)-N,N-dimethyl-3-(naphthalene-1-yloxy)-1-phenylPropan-1-amine, a premature ejaculation in bulk drugs. The enantiomer of Dapoxetine hydrochloride were baseline resolved on a Phenomenex Lux-cellulose-1 (250mm×4.6 mm, 5um) column using a mobile phase system containing hexane: 1-propanol: diethyl amine (97.5:2.5:0.1, v/v/v). The resolution between the enantiomer was not less than 3.5 and interestingly distomer was eluted prior to eutomer in the developed method. The presence of diethyl amine and 1-propanol in the mobile phase has played an important role in enhancing chromatographic efficiency and resolution between the enantiomers. The developed method was extensively validated and proved to be robust. The detection limit and quantitation limit of (R)-enantiomer were found to be 0.017% and 0.05%, respectively. The recovery of (R)-enantiomer was ranged from 90110% in bulk drug samples. Dapoxetine hydrochloride sample solution and mobile phase were found to be stable for at least 48 h. The proposed method was found to be suitable and accurate for the quantitative determination of (R)-enantiomer in bulk drugs." @default.
- W2302888901 created "2016-06-24" @default.
- W2302888901 creator A5009682578 @default.
- W2302888901 date "2012-01-01" @default.
- W2302888901 modified "2023-09-24" @default.
- W2302888901 title "A validated chiral liquid chromatographic method for the enantiomeric separation of Dapoxetine Hydrochloride" @default.
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