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- W2302939832 abstract "Aim: To explore predictors of remission for patients with treatment-resistant MDD receiving quetiapine XR.Methods: Post-hoc analysis of data from a 6-week, randomised, open-label, rater-blinded study (NCT00789854) in adults with treatment-resistant MDD (non-responders to 1 or 2 adequate trials of major classes of antidepressant [AD], MADRS total score ≥ 25). Treatment: add-on quetiapine XR (300 mg/day) to ongoing AD therapy, quetiapine XR monotherapy (300 mg/day) or add-on lithium (0.6–1.2 mmol/L). Primary efficacy evaluation: change in MADRS total score from randomisation to Week 6 (pre-specified non-inferiority limit 3 points). Remission definition: MADRS total score ≤ 10 points; a univariate logistic regression approach was used to determine variables predictive for remission.Results: 688 patients randomised (add-on quetiapine XR [n = 231], quetiapine XR monotherapy [n = 228], add-on lithium [n = 229]). At Week 6, add-on quetiapine XR and quetiapine XR monotherapy were non-inferior to add-on lithium; least squares mean differences in MADRS total score changes: −2.32 (95% confidence interval [CI]: −4.6, −0.05), which is above the 2 points judged to be clinically relevant, and −0.97 (95% CI: −3.24, 1.31), respectively. MADRS remission rates: 31.9%, 23.6% and 27.1% for add-on quetiapine XR, quetiapine XR monotherapy and add-on lithium, respectively (no significant differences between groups). The post-hoc analysis identified 22/127 variables that had predictive value for remission including time since first known psychiatric disorder (p 50% improvement in MADRS total score) was predicted by the same variables as for remission.Conclusions: Time and anxiety variables offered the greatest predictive value, with longer time or higher anxiety associated with a lower likelihood of attaining symptomatic remission or response." @default.
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- W2302939832 date "2010-11-01" @default.
- W2302939832 modified "2023-10-18" @default.
- W2302939832 title "[Not Available]." @default.
- W2302939832 doi "https://doi.org/10.3109/13651501.2010.527734" @default.
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