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- W2303306784 abstract "Impulsive aggression has commonly been associated with a dysfunction of the serotonin (5-HT) system: many, but not all, studies point to an inverse relationship between 5-HT and aggression. As cerebral 5-HT 4 receptor (5-HT 4 R) binding has recently been recognized as a proxy for stable brain levels of 5-HT, we here test the hypothesis in healthy men and women that brain 5-HT levels, as indexed by cerebral 5-HT 4 R, are inversely correlated with trait aggression and impulsivity. Sixty-one individuals (47 men) underwent positron emission tomography scanning with the radioligand [ 11 C]SB207145 for quantification of brain 5-HT 4 R binding. The Buss–Perry Aggression Questionnaire (BPAQ) and the Barratt Impulsiveness Scale were used for assessment of trait aggression and trait impulsivity. Among male subjects, there was a positive correlation between global 5-HT 4 R and BPAQ total score ( P = 0.037) as well as BPAQ physical aggression ( P = 0.025). No main effect of global 5-HT 4 R on trait aggression or impulsivity was found in the mixed gender sample, but there was evidence for sex interaction effects in the relationship between global 5-HT 4 R and BPAQ physical aggression. In conclusion we found that low cerebral 5-HT levels, as indexed by 5-HT 4 R binding were associated with high trait aggression in males, but not in females." @default.
- W2303306784 created "2016-06-24" @default.
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- W2303306784 date "2016-01-15" @default.
- W2303306784 modified "2023-10-06" @default.
- W2303306784 title "High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT 4 receptor binding" @default.
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- W2303306784 doi "https://doi.org/10.1093/scan/nsv140" @default.
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