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- W2303334402 abstract "survival with fulvestrant 500 mg compared with anastrozole in the first-line setting for ER-positive ABC. For the first time to our knowledge, an endocrine monotherapy strategy demonstrated improved efficacy compared with aromatase inhibition. The phase II FIRST (Fulvestrant First-Line Study Comparing Endocrine Treatments) trial raises some issues common to most if not all published trials on ET for ABC. Although considered a first-line ABC trial, FIRST included two distinct popu lations of patients with presumably different responses to ET. The trial included a majority of patients never exposed to ET and a group of patients previously treated with adjuvant tamoxifen. Overall, first-line fulvestrant improved overall survival compared with anastrozole. Interestingly," @default.
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- W2303334402 date "2016-06-01" @default.
- W2303334402 modified "2023-09-27" @default.
- W2303334402 title "Definition of First-Line Endocrine Therapy for Hormone Receptor–Positive Advanced Breast Cancer" @default.
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- W2303334402 doi "https://doi.org/10.1200/jco.2015.66.0803" @default.
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