FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2303426518> ?p ?o ?g. }

• W2303426518 abstract "Abstract Background Neutrophils are able to trap and kill microbes via the release of their DNA decorated with proteins from granule and histones into the extracellular environment; however, this mechanism has also emerged as a potential source of auto-antigens and inflammation during the course of many autoimmune diseases. It has been demonstrated that neutrophils from patients with rheumatoid arthritis (RA) have a greater propensity to release neutrophil extracellular traps (NETs). DNAse I, an endonuclease involved in the breakdown of chromatin, has been implicated in the pathophysiology of autoimmune diseases. Aim of the work To investigate the genetic associations of a non-synonymous single nucleotide polymorphism (SNP) in DNAse I with the risk of RA and its influence on clinical and radiographic features in an Argentinean population. Patients and methods The Q222R A/G DNAse I SNP was studied in 210 RA patients and 206 matched healthy controls. Disease activity score, health assessment questionnaire and the modified Sharp van der Heijde score were assessed. Results The patients’ median age was 56 years (48–64), disease duration 128 months (20–205) and 86.7% were females. Genotype distribution and G-allele frequency were comparable between patients and control. There was no significant association of the Q222R A/G genotypes with disease susceptibility, activity, functional status or radiological score among RA Argentine patients. Conclusions No significant genetic association was found between the carriage of the DNAse I Q222R G-allele and the risk of RA nor was there any association with the disease activity, functional capacity or severity in an Argentine patient cohort." @default.
• W2303426518 created "2016-06-24" @default.
• W2303426518 creator A5000519322 @default.
• W2303426518 creator A5009866254 @default.
• W2303426518 creator A5022584231 @default.
• W2303426518 creator A5023546634 @default.
• W2303426518 creator A5024180414 @default.
• W2303426518 creator A5027645045 @default.
• W2303426518 creator A5038963243 @default.
• W2303426518 creator A5041943265 @default.
• W2303426518 creator A5072976012 @default.
• W2303426518 creator A5081027436 @default.
• W2303426518 creator A5082237505 @default.
• W2303426518 date "2016-10-01" @default.
• W2303426518 modified "2023-09-22" @default.
• W2303426518 title "Q222R polymorphism in the DNAse I gene is not associated with susceptibility to rheumatoid arthritis or to disease course in an Argentine patient cohort" @default.
• W2303426518 cites W1534043095 @default.
• W2303426518 cites W1567114372 @default.
• W2303426518 cites W1572925458 @default.
• W2303426518 cites W1601068182 @default.
• W2303426518 cites W1831672189 @default.
• W2303426518 cites W1867131794 @default.
• W2303426518 cites W1981899830 @default.
• W2303426518 cites W1985083442 @default.
• W2303426518 cites W1986282241 @default.
• W2303426518 cites W1992687368 @default.
• W2303426518 cites W1998307301 @default.
• W2303426518 cites W2015546947 @default.
• W2303426518 cites W2020749989 @default.
• W2303426518 cites W2033753616 @default.
• W2303426518 cites W2043756611 @default.
• W2303426518 cites W2045819100 @default.
• W2303426518 cites W2050211984 @default.
• W2303426518 cites W2050975242 @default.
• W2303426518 cites W2067022007 @default.
• W2303426518 cites W2068293342 @default.
• W2303426518 cites W2070117107 @default.
• W2303426518 cites W2072460496 @default.
• W2303426518 cites W2078817520 @default.
• W2303426518 cites W2093756791 @default.
• W2303426518 cites W2102079012 @default.
• W2303426518 cites W2104934425 @default.
• W2303426518 cites W2109178826 @default.
• W2303426518 cites W2110177517 @default.
• W2303426518 cites W2110826367 @default.
• W2303426518 cites W2114870726 @default.
• W2303426518 cites W2115959782 @default.
• W2303426518 cites W2121134187 @default.
• W2303426518 cites W2126774943 @default.
• W2303426518 cites W2134923719 @default.
• W2303426518 cites W2135849676 @default.
• W2303426518 cites W2140815625 @default.
• W2303426518 cites W2141522272 @default.
• W2303426518 cites W2145019007 @default.
• W2303426518 cites W2150490016 @default.
• W2303426518 cites W2152348310 @default.
• W2303426518 cites W2152818840 @default.
• W2303426518 cites W2157558787 @default.
• W2303426518 cites W2161424509 @default.
• W2303426518 cites W2168176302 @default.
• W2303426518 cites W2333540045 @default.
• W2303426518 cites W2614982836 @default.
• W2303426518 doi "https://doi.org/10.1016/j.ejr.2016.02.006" @default.
• W2303426518 hasPublicationYear "2016" @default.
• W2303426518 type Work @default.
• W2303426518 sameAs 2303426518 @default.
• W2303426518 citedByCount "1" @default.
• W2303426518 countsByYear W23034265182016 @default.
• W2303426518 crossrefType "journal-article" @default.
• W2303426518 hasAuthorship W2303426518A5000519322 @default.
• W2303426518 hasAuthorship W2303426518A5009866254 @default.
• W2303426518 hasAuthorship W2303426518A5022584231 @default.
• W2303426518 hasAuthorship W2303426518A5023546634 @default.
• W2303426518 hasAuthorship W2303426518A5024180414 @default.
• W2303426518 hasAuthorship W2303426518A5027645045 @default.
• W2303426518 hasAuthorship W2303426518A5038963243 @default.
• W2303426518 hasAuthorship W2303426518A5041943265 @default.
• W2303426518 hasAuthorship W2303426518A5072976012 @default.
• W2303426518 hasAuthorship W2303426518A5081027436 @default.
• W2303426518 hasAuthorship W2303426518A5082237505 @default.
• W2303426518 hasBestOaLocation W23034265181 @default.
• W2303426518 hasConcept C104317684 @default.
• W2303426518 hasConcept C126322002 @default.
• W2303426518 hasConcept C134897094 @default.
• W2303426518 hasConcept C135763542 @default.
• W2303426518 hasConcept C139275648 @default.
• W2303426518 hasConcept C153209595 @default.
• W2303426518 hasConcept C180754005 @default.
• W2303426518 hasConcept C203014093 @default.
• W2303426518 hasConcept C2776914184 @default.
• W2303426518 hasConcept C2777077863 @default.
• W2303426518 hasConcept C2777575956 @default.
• W2303426518 hasConcept C2779075594 @default.
• W2303426518 hasConcept C2779134260 @default.
• W2303426518 hasConcept C54355233 @default.
• W2303426518 hasConcept C71924100 @default.
• W2303426518 hasConcept C72563966 @default.
• W2303426518 hasConcept C86803240 @default.
• W2303426518 hasConceptScore W2303426518C104317684 @default.
• W2303426518 hasConceptScore W2303426518C126322002 @default.

• next