FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2303715743> ?p ?o ?g. }

• W2303715743 endingPage "e0152135" @default.
• W2303715743 startingPage "e0152135" @default.
• W2303715743 abstract "Hibernation is a strategy used by some mammals to survive a cold winter. Small hibernating mammals, such as squirrels and hamsters, use species- and tissue-specific antioxidant defenses to cope with oxidative insults during hibernation. Little is known about antioxidant responses and their regulatory mechanisms in hibernating bats. We found that the total level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the brain of each of the two distantly related hibernating bats M. ricketti and R. ferrumequinum at arousal was lower than that at torpid or active state. We also found that the levels of malondialdehyde (product of lipid peroxidation) of the two hibernating species of bats were significantly lower than those of non-hibernating bats R. leschenaultia and C. sphinx. This observation suggests that bats maintain a basal level of ROS/RNS that does no harm to the brain during hibernation. Results of Western blotting showed that hibernating bats expressed higher amounts of antioxidant proteins than non-hibernating bats and that M. ricketti bats upregulated the expression of some enzymes to overcome oxidative stresses, such as superoxide dismutase, glutathione reductase, and catalase. In contrast, R. ferrumequinum bats maintained a relatively high level of superoxide dismutase 2, glutathione reductase, and thioredoxin-2 throughout the three different states of hibernation cycles. The levels of glutathione (GSH) were higher in M. ricketti bats than in R. ferrumequinum bats and were significantly elevated in R. ferrumequinum bats after torpor. These data suggest that M. ricketti bats use mainly antioxidant enzymes and R. ferrumequinum bats rely on both enzymes and low molecular weight antioxidants (e.g., glutathione) to avoid oxidative stresses during arousal. Furthermore, Nrf2 and FOXOs play major roles in the regulation of antioxidant defenses in the brains of bats during hibernation. Our study revealed strategies used by bats against oxidative insults during hibernation." @default.
• W2303715743 created "2016-06-24" @default.
• W2303715743 creator A5001483377 @default.
• W2303715743 creator A5008149300 @default.
• W2303715743 creator A5008728096 @default.
• W2303715743 creator A5018808903 @default.
• W2303715743 creator A5035990983 @default.
• W2303715743 creator A5045814399 @default.
• W2303715743 date "2016-03-24" @default.
• W2303715743 modified "2023-10-14" @default.
• W2303715743 title "Antioxidant Defenses in the Brains of Bats during Hibernation" @default.
• W2303715743 cites W1500923019 @default.
• W2303715743 cites W1522955826 @default.
• W2303715743 cites W1567433907 @default.
• W2303715743 cites W1605667856 @default.
• W2303715743 cites W1951314249 @default.
• W2303715743 cites W1969170205 @default.
• W2303715743 cites W1973175580 @default.
• W2303715743 cites W1973732693 @default.
• W2303715743 cites W1977859279 @default.
• W2303715743 cites W1980010444 @default.
• W2303715743 cites W1980739328 @default.
• W2303715743 cites W1985776151 @default.
• W2303715743 cites W1986272205 @default.
• W2303715743 cites W1987920328 @default.
• W2303715743 cites W1989987141 @default.
• W2303715743 cites W1992125680 @default.
• W2303715743 cites W1993433343 @default.
• W2303715743 cites W1995219619 @default.
• W2303715743 cites W1996024251 @default.
• W2303715743 cites W1997655974 @default.
• W2303715743 cites W1999055613 @default.
• W2303715743 cites W1999273706 @default.
• W2303715743 cites W1999718232 @default.
• W2303715743 cites W2000873756 @default.
• W2303715743 cites W2009556882 @default.
• W2303715743 cites W2012645913 @default.
• W2303715743 cites W2015243552 @default.
• W2303715743 cites W2017856783 @default.
• W2303715743 cites W2018058537 @default.
• W2303715743 cites W2023552355 @default.
• W2303715743 cites W2023656275 @default.
• W2303715743 cites W2024394407 @default.
• W2303715743 cites W2026841498 @default.
• W2303715743 cites W2028403883 @default.
• W2303715743 cites W2029463263 @default.
• W2303715743 cites W2030046577 @default.
• W2303715743 cites W2032088933 @default.
• W2303715743 cites W2038005840 @default.
• W2303715743 cites W2038699613 @default.
• W2303715743 cites W2039262033 @default.
• W2303715743 cites W2044704936 @default.
• W2303715743 cites W2052701721 @default.
• W2303715743 cites W2053063855 @default.
• W2303715743 cites W2064300184 @default.
• W2303715743 cites W2079310705 @default.
• W2303715743 cites W2079788350 @default.
• W2303715743 cites W2081680109 @default.
• W2303715743 cites W2082836748 @default.
• W2303715743 cites W2087790613 @default.
• W2303715743 cites W2088265030 @default.
• W2303715743 cites W2096094438 @default.
• W2303715743 cites W2098845312 @default.
• W2303715743 cites W2104109524 @default.
• W2303715743 cites W2104603317 @default.
• W2303715743 cites W2115044387 @default.
• W2303715743 cites W2120282383 @default.
• W2303715743 cites W2121966499 @default.
• W2303715743 cites W2125289626 @default.
• W2303715743 cites W2128733166 @default.
• W2303715743 cites W2139856782 @default.
• W2303715743 cites W2144361706 @default.
• W2303715743 cites W2146254669 @default.
• W2303715743 cites W2146558971 @default.
• W2303715743 cites W2158042178 @default.
• W2303715743 cites W2165201727 @default.
• W2303715743 cites W2170022444 @default.
• W2303715743 cites W32197805 @default.
• W2303715743 cites W76948958 @default.
• W2303715743 doi "https://doi.org/10.1371/journal.pone.0152135" @default.
• W2303715743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4806925" @default.
• W2303715743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27010916" @default.
• W2303715743 hasPublicationYear "2016" @default.
• W2303715743 type Work @default.
• W2303715743 sameAs 2303715743 @default.
• W2303715743 citedByCount "34" @default.
• W2303715743 countsByYear W23037157432016 @default.
• W2303715743 countsByYear W23037157432017 @default.
• W2303715743 countsByYear W23037157432018 @default.
• W2303715743 countsByYear W23037157432019 @default.
• W2303715743 countsByYear W23037157432020 @default.
• W2303715743 countsByYear W23037157432021 @default.
• W2303715743 countsByYear W23037157432022 @default.
• W2303715743 countsByYear W23037157432023 @default.
• W2303715743 crossrefType "journal-article" @default.
• W2303715743 hasAuthorship W2303715743A5001483377 @default.
• W2303715743 hasAuthorship W2303715743A5008149300 @default.
• W2303715743 hasAuthorship W2303715743A5008728096 @default.

• next