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- W2303840283 abstract "The Protein Arginine Deiminases (PADs) are a small family of human enzymes that catalyze the post-translational hydrolysis of arginine residues to generate citrulline. These enzymes are important regulators of gene transcription and their activity is upregulated in multiple inflammatory diseases, including rheumatoid arthritis, ulcerative colitis, and cancer. Herein, I will discuss our efforts to develop chemical probes targeting the PADs and protein citrullination, focusing on our success in validating the PADs as therapeutic targets, as well as our more recent efforts to develop phenylglyoxal based reagents that can be used to readily visualize protein citrullination and identify disease biomarkers. Additionally, I will describe our efforts, both crystallographic and enzymological, to understand how calcium regulates the activity and nuclear localization of PAD2." @default.
- W2303840283 created "2016-06-24" @default.
- W2303840283 creator A5059551211 @default.
- W2303840283 date "2015-04-01" @default.
- W2303840283 modified "2023-10-03" @default.
- W2303840283 title "Picking the PADlock: Chemical Probes to Study the Protein Arginine Deiminases" @default.
- W2303840283 doi "https://doi.org/10.1096/fasebj.29.1_supplement.224.1" @default.
- W2303840283 hasPublicationYear "2015" @default.
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