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• W2303912267 abstract "The interactions of the water-soluble tetraazaperopyrene dye 1 with ct-DNA, duplex-[(dAdT)12 ⋅(dAdT)12 ], duplex-[(dGdC)12 ⋅(dGdC)12 ] as well as with two G-quadruplex-forming sequences, namely the human telomeric 22AG and the promotor sequence c-myc, were investigated by means of UV/visible and fluorescence spectroscopy, isothermal titration calorimetry (ITC) and molecular docking studies. Dye 1 exhibits a high affinity for G-quadruplex structures over duplex DNA structures. Furthermore, the ligand shows promising G-quadruplex discrimination, with an affinity towards c-myc of 2×10(7)  m(-1) (i.e., Kd =50 nm), which is higher than for 22AG (4×10(6)  m(-1) ). The ITC data reveal that compound 1 interacts with c-myc in a stoichiometric ratio of 1:1 but also indicate the presence of two identical lower affinity secondary binding sites per quadruplex. In 22AG, there are two high affinity binding sites per quadruplex, that is, one on each side, with a further four weaker binding sites. For both quadruplex structures, the high affinity interactions between compound 1 and the quadruplex-forming nucleic acid structures are weakly endothermic. Molecular docking studies suggest an end-stacking binding mode for compound 1 interacting with quadruplex structures, and a higher affinity for the parallel conformation of c-myc than for the mixed-hybrid conformation of 22AG. In addition, docking studies also suggest that the reduced affinity for duplex DNA structures is due to the non-viability of an intercalative binding mode." @default.
• W2303912267 created "2016-06-24" @default.
• W2303912267 creator A5053114480 @default.
• W2303912267 creator A5066055309 @default.
• W2303912267 creator A5076922792 @default.
• W2303912267 date "2016-03-21" @default.
• W2303912267 modified "2023-10-17" @default.
• W2303912267 title "A Water-Soluble Tetraazaperopyrene Dye as Strong G-Quadruplex DNA Binder" @default.
• W2303912267 cites W1450574606 @default.
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• W2303912267 cites W1583064311 @default.
• W2303912267 cites W1789563956 @default.
• W2303912267 cites W1810809543 @default.
• W2303912267 cites W1935462445 @default.
• W2303912267 cites W1938216854 @default.
• W2303912267 cites W1963835380 @default.
• W2303912267 cites W1966564432 @default.
• W2303912267 cites W1972187528 @default.
• W2303912267 cites W1973337106 @default.
• W2303912267 cites W1980849347 @default.
• W2303912267 cites W1989226481 @default.
• W2303912267 cites W1989366551 @default.
• W2303912267 cites W1991797965 @default.
• W2303912267 cites W1995599669 @default.
• W2303912267 cites W1995943720 @default.
• W2303912267 cites W1997586605 @default.
• W2303912267 cites W2003122343 @default.
• W2303912267 cites W2003842226 @default.
• W2303912267 cites W2007814891 @default.
• W2303912267 cites W2008120871 @default.
• W2303912267 cites W2008182786 @default.
• W2303912267 cites W2010882280 @default.
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• W2303912267 cites W2050087016 @default.
• W2303912267 cites W2053166926 @default.
• W2303912267 cites W2057916029 @default.
• W2303912267 cites W2059306569 @default.
• W2303912267 cites W2059347009 @default.
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• W2303912267 cites W2085979102 @default.
• W2303912267 cites W2086463530 @default.
• W2303912267 cites W2091451604 @default.
• W2303912267 cites W2092058466 @default.
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• W2303912267 cites W2251344425 @default.
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• W2303912267 cites W2321091140 @default.
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• W2303912267 doi "https://doi.org/10.1002/chem.201504934" @default.
• W2303912267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5071672" @default.
• W2303912267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26997208" @default.
• W2303912267 hasPublicationYear "2016" @default.
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