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• W2304033365 abstract "1. On the travel of ribosomes toward and along the cytoplasmic membrane: An essential pathway for proper biosynthesis of integral membrane proteins. Cytoplasmic membrane proteins have indispensable functions in cellular physiology, metabolism, structure and communication. In all living cells the biogenesis of these proteins requires the Signal Recognition Particle (SRP) system (Fig. 1A), which mediates there translation on membranebound ribosomes. We are studying central mechanistic and structural aspects of the SRP system in E. coli, in the context of the biosynthetic pathway of membrane proteins. We have demonstrated that the bacterial homologue of the mammalian SRP receptor (FtsY) is essential for targeting ribosomes to the membrane and for expression of membrane proteins. In contrast, in the absence of the SRP itself, ribosome targeting and membrane protein synthesis continue, although their proper assembly is severely impaired. These observations, combined with additional considerations, led us to propose a testable model for ribosome targeting in E. coli (Fig. 1B). We propose that ribosomes are targeted to the membrane in an SRP-receptor-dependent, SRPindependent manner. After targeting, the transfer of ribosomes to the membrane insertion machinery is mediated by SRP. This scenario implies that the SRP might function downstream to the SRP receptor during the biosynthesis of membrane proteins. This model is currently being investigated using genetic screens, biochemical tools and structural analyses. These studies will clarify the order of events during the biosynthetic pathway of membrane proteins and the mechanism by which membranes are equipped with ribosomes." @default.
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• W2304033365 date "2001-01-01" @default.
• W2304033365 modified "2023-10-03" @default.
• W2304033365 title "Biogenesis, structure and function of membrane transport proteins" @default.
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