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• W2304256252 abstract "<h3>Objective:</h3> To investigate the cross-sectional and longitudinal associations of 10-second heart rate variability (HRV) with various domains of cognitive function in older participants at risk of cardiovascular disease. <h3>Methods:</h3> We studied 3,583 participants, mean age of 75.0 years, who were enrolled in the Prospective Study of Pravastatin in the Elderly at Risk. From baseline 10-second ECGs, standard deviation of normal-to-normal intervals was calculated as the index of HRV. Four cognitive domains were assessed at baseline and repeated during a mean follow-up period of 3.2 years. <h3>Results:</h3> Lower HRV at baseline was associated with worse performance in reaction time (mean difference between low third vs high third of HRV = 1.96 seconds, 95% confidence interval [CI] 0.20 to 3.71) and processing speed (−0.57 digits coded, 95% CI −1.09 to −0.05). During follow-up, participants with lower HRV had a steeper decline in processing speed (mean annual change between low third vs high third of HRV = −0.16 digits coded, 95% CI −0.28 to −0.04). There was no difference in annual changes of reaction time or immediate and delayed memory among HRV thirds during follow-up. All these associations remained unchanged after adjustment for medications, cardiovascular risk factors, and comorbidities. <h3>Conclusions:</h3> Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities." @default.
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• W2304256252 date "2016-02-17" @default.
• W2304256252 modified "2023-09-26" @default.
• W2304256252 title "10-Second heart rate variability and cognitive function in old age" @default.
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• W2304256252 doi "https://doi.org/10.1212/wnl.0000000000002499" @default.
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