FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2304404792> ?p ?o ?g. }

• W2304404792 endingPage "e0146165" @default.
• W2304404792 startingPage "e0146165" @default.
• W2304404792 abstract "Purpose The emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified. Methods In this study, we used a multidisciplinary approach to gain insight into the antibacterial mechanism of this compound. Results The antibacterial activity of kendomycin appears to be bacteriostatic rather than bactericidal. Kendomycin inhibited the growth of the MRSA strain COL at a low concentration (MIC of 5 μg/mL). Proteomic analysis and gene transcription profiling of kendomycin-treated cells indicated that this compound affected the regulation of numerous proteins and genes involved in central metabolic pathways, such as the tricarboxylic acid (TCA) cycle (SdhA) and gluconeogenesis (PckA and GapB), cell wall biosynthesis and cell division (FtsA, FtsZ, and MurAA), capsule production (Cap5A and Cap5C), bacterial programmed cell death (LrgA and CidA), the cellular stress response (ClpB, ClpC, ClpP, GroEL, DnaK, and GrpE), and oxidative stress (AhpC and KatA). Electron microscopy revealed that kendomycin strongly affected septum formation during cell division. Most kendomycin-treated cells displayed incomplete septa with abnormal morphology. Conclusions Kendomycin might directly or indirectly affect the cell division machinery, protein stability, and programmed cell death in S. aureus. Additional studies are still needed to obtain deeper insight into the mode of action of kendomycin." @default.
• W2304404792 created "2016-06-24" @default.
• W2304404792 creator A5012152118 @default.
• W2304404792 creator A5016986473 @default.
• W2304404792 creator A5030101766 @default.
• W2304404792 creator A5039627923 @default.
• W2304404792 creator A5057112424 @default.
• W2304404792 creator A5065711340 @default.
• W2304404792 creator A5074731062 @default.
• W2304404792 creator A5077818118 @default.
• W2304404792 date "2016-01-21" @default.
• W2304404792 modified "2023-10-14" @default.
• W2304404792 title "Investigations to the Antibacterial Mechanism of Action of Kendomycin" @default.
• W2304404792 cites W1485195637 @default.
• W2304404792 cites W1538899778 @default.
• W2304404792 cites W1539516473 @default.
• W2304404792 cites W1558571934 @default.
• W2304404792 cites W1774855051 @default.
• W2304404792 cites W1901667800 @default.
• W2304404792 cites W1938713654 @default.
• W2304404792 cites W1970975268 @default.
• W2304404792 cites W1972770043 @default.
• W2304404792 cites W1979591640 @default.
• W2304404792 cites W1981050129 @default.
• W2304404792 cites W1982728268 @default.
• W2304404792 cites W1984554167 @default.
• W2304404792 cites W1984733771 @default.
• W2304404792 cites W1986207312 @default.
• W2304404792 cites W1994762646 @default.
• W2304404792 cites W1995405638 @default.
• W2304404792 cites W1995753588 @default.
• W2304404792 cites W2007028496 @default.
• W2304404792 cites W2008318863 @default.
• W2304404792 cites W2009989026 @default.
• W2304404792 cites W2013106975 @default.
• W2304404792 cites W2027978639 @default.
• W2304404792 cites W2036158497 @default.
• W2304404792 cites W2052674385 @default.
• W2304404792 cites W2063361328 @default.
• W2304404792 cites W2067148638 @default.
• W2304404792 cites W2069018149 @default.
• W2304404792 cites W2073525898 @default.
• W2304404792 cites W2076272826 @default.
• W2304404792 cites W2078229107 @default.
• W2304404792 cites W2084366893 @default.
• W2304404792 cites W2085203527 @default.
• W2304404792 cites W2087491749 @default.
• W2304404792 cites W2092553992 @default.
• W2304404792 cites W2104134882 @default.
• W2304404792 cites W2109500035 @default.
• W2304404792 cites W2112034821 @default.
• W2304404792 cites W2112338150 @default.
• W2304404792 cites W2117437351 @default.
• W2304404792 cites W2117908823 @default.
• W2304404792 cites W2120160920 @default.
• W2304404792 cites W2126044069 @default.
• W2304404792 cites W2126547747 @default.
• W2304404792 cites W2127773968 @default.
• W2304404792 cites W2128139766 @default.
• W2304404792 cites W2129702572 @default.
• W2304404792 cites W2135939299 @default.
• W2304404792 cites W2141562167 @default.
• W2304404792 cites W2142237909 @default.
• W2304404792 cites W2142779706 @default.
• W2304404792 cites W2142994579 @default.
• W2304404792 cites W2144121476 @default.
• W2304404792 cites W2144243750 @default.
• W2304404792 cites W2144801144 @default.
• W2304404792 cites W2145606282 @default.
• W2304404792 cites W2146893712 @default.
• W2304404792 cites W2147280469 @default.
• W2304404792 cites W2147798082 @default.
• W2304404792 cites W2151454486 @default.
• W2304404792 cites W2158978167 @default.
• W2304404792 cites W2161809782 @default.
• W2304404792 cites W2163562422 @default.
• W2304404792 cites W2166442724 @default.
• W2304404792 cites W2167639479 @default.
• W2304404792 cites W2171998389 @default.
• W2304404792 cites W2950929366 @default.
• W2304404792 cites W4250915697 @default.
• W2304404792 cites W82888975 @default.
• W2304404792 cites W88880418 @default.
• W2304404792 doi "https://doi.org/10.1371/journal.pone.0146165" @default.
• W2304404792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4721675" @default.
• W2304404792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26795276" @default.
• W2304404792 hasPublicationYear "2016" @default.
• W2304404792 type Work @default.
• W2304404792 sameAs 2304404792 @default.
• W2304404792 citedByCount "14" @default.
• W2304404792 countsByYear W23044047922016 @default.
• W2304404792 countsByYear W23044047922017 @default.
• W2304404792 countsByYear W23044047922019 @default.
• W2304404792 countsByYear W23044047922020 @default.
• W2304404792 countsByYear W23044047922021 @default.
• W2304404792 countsByYear W23044047922022 @default.
• W2304404792 countsByYear W23044047922023 @default.
• W2304404792 crossrefType "journal-article" @default.

• next