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- W2304641330 endingPage "611" @default.
- W2304641330 startingPage "605" @default.
- W2304641330 abstract "Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations. Both of these issues, also commonly experienced with small molecule drugs, have been addressed effectively in a number of cases by the successful application of pharmacogenomic tools and approaches. In this introductory article of the special issue, we review the current state of application of pharmacogenomics to BTs and offer suggestions for further expansion of the field." @default.
- W2304641330 created "2016-06-24" @default.
- W2304641330 creator A5042096923 @default.
- W2304641330 date "2016-03-23" @default.
- W2304641330 modified "2023-10-17" @default.
- W2304641330 title "Recent Advances in Application of Pharmacogenomics for Biotherapeutics" @default.
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- W2304641330 doi "https://doi.org/10.1208/s12248-016-9903-4" @default.
- W2304641330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5256619" @default.
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- W2304641330 hasPublicationYear "2016" @default.
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