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- W2304702310 abstract "Abstract Venezuelan equine encephalitis virus (VEEV) generally causes a mild febrile illness; however, a subset of patients,primarily children,develops lethal encephalitis. The virus requires high level biocontainment (BSL3) limiting the use of many research tools. A model of VEEV-like encephalitis that can be utilized to determine the protective host response to disease development is needed to study the mechanisms of immunoprotection. We hypothesized that intranasal inoculation of TC83, an attenuated strain of VEEV,in α/B TCR KO mice would mimic VEEV encephalitis. Infected α/B TCR KO developed signs of illness including significant weight loss,as compared to controls,but all mice fully recovered from infection. Viral titers at the peak of illness reached surprisingly high levels in the brain (log 9- log 10). These levels were reduced (log 3- log 5). Surprisingly, similar low levels of virus were maintained indicating the ability of TC83 to persist in the brain. Visceral organs had low level of virus present during acute infection only. The reduction of infection occurred in the absence of T cells and detectable neutralizing antibody levels. Infection-induced transcriptomes in the brain of the murine host as well as cytokine protein levels demonstrated elevated levels of IL-12(p40), INF-β, MCP-1, MIP-1α, MIP-1β, and RANTES. TGF-β was below the limit of detection. This model represents a unique situation to study acute viral response and chronic viral persistence in the CNS." @default.
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- W2304702310 date "2010-04-01" @default.
- W2304702310 modified "2023-09-26" @default.
- W2304702310 title "A novel model to study lethal vs. non-lethal viral encephalitis (43.1)" @default.
- W2304702310 doi "https://doi.org/10.4049/jimmunol.184.supp.43.1" @default.
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