Matches in SemOpenAlex for { <https://semopenalex.org/work/W230497445> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W230497445 abstract "Abstract : The goal of this work is to develop novel, efficacious, injectable, gene-specific therapeutics for treatment of human immunodeficiency virus (HIV) infection. These products will be nuclease resistant, stereospecific antisense inhibitors of human immunodeficiency virus gene expression and activity. Antisense DNA inhibition has worked in this laboratory against several human and viral genes in cell culture. In this project, routes are being developed for the stereospecific synthesis and purification of all-S or all-R oligodeoxynucleoside methylphosphonates directed against specific HIV mRNAs, and against tat protein. Several dimers have been prepared by the pentavalent solution route, and encouraging results have been obtained for the trivalent solution route." @default.
- W230497445 created "2016-06-24" @default.
- W230497445 creator A5018474662 @default.
- W230497445 date "1989-03-20" @default.
- W230497445 modified "2023-09-24" @default.
- W230497445 title "Antisense Oligodeoxynucleotide Inhibition of HIV Gene Expression" @default.
- W230497445 doi "https://doi.org/10.21236/ada239086" @default.
- W230497445 hasPublicationYear "1989" @default.
- W230497445 type Work @default.
- W230497445 sameAs 230497445 @default.
- W230497445 citedByCount "0" @default.
- W230497445 crossrefType "report" @default.
- W230497445 hasAuthorship W230497445A5018474662 @default.
- W230497445 hasConcept C104317684 @default.
- W230497445 hasConcept C111599444 @default.
- W230497445 hasConcept C150194340 @default.
- W230497445 hasConcept C153911025 @default.
- W230497445 hasConcept C159047783 @default.
- W230497445 hasConcept C185592680 @default.
- W230497445 hasConcept C2522874641 @default.
- W230497445 hasConcept C2777271071 @default.
- W230497445 hasConcept C3013748606 @default.
- W230497445 hasConcept C552990157 @default.
- W230497445 hasConcept C55493867 @default.
- W230497445 hasConcept C86803240 @default.
- W230497445 hasConceptScore W230497445C104317684 @default.
- W230497445 hasConceptScore W230497445C111599444 @default.
- W230497445 hasConceptScore W230497445C150194340 @default.
- W230497445 hasConceptScore W230497445C153911025 @default.
- W230497445 hasConceptScore W230497445C159047783 @default.
- W230497445 hasConceptScore W230497445C185592680 @default.
- W230497445 hasConceptScore W230497445C2522874641 @default.
- W230497445 hasConceptScore W230497445C2777271071 @default.
- W230497445 hasConceptScore W230497445C3013748606 @default.
- W230497445 hasConceptScore W230497445C552990157 @default.
- W230497445 hasConceptScore W230497445C55493867 @default.
- W230497445 hasConceptScore W230497445C86803240 @default.
- W230497445 hasLocation W2304974451 @default.
- W230497445 hasOpenAccess W230497445 @default.
- W230497445 hasPrimaryLocation W2304974451 @default.
- W230497445 hasRelatedWork W141076855 @default.
- W230497445 hasRelatedWork W1484402394 @default.
- W230497445 hasRelatedWork W1523630821 @default.
- W230497445 hasRelatedWork W1975239230 @default.
- W230497445 hasRelatedWork W1979161512 @default.
- W230497445 hasRelatedWork W1988646188 @default.
- W230497445 hasRelatedWork W1997823436 @default.
- W230497445 hasRelatedWork W2001283201 @default.
- W230497445 hasRelatedWork W2008085654 @default.
- W230497445 hasRelatedWork W2010496733 @default.
- W230497445 hasRelatedWork W2057633014 @default.
- W230497445 hasRelatedWork W2111807418 @default.
- W230497445 hasRelatedWork W2156505764 @default.
- W230497445 hasRelatedWork W2171711893 @default.
- W230497445 hasRelatedWork W2301483095 @default.
- W230497445 hasRelatedWork W2334611325 @default.
- W230497445 hasRelatedWork W2417861565 @default.
- W230497445 hasRelatedWork W35488032 @default.
- W230497445 hasRelatedWork W40691186 @default.
- W230497445 hasRelatedWork W1907359641 @default.
- W230497445 isParatext "false" @default.
- W230497445 isRetracted "false" @default.
- W230497445 magId "230497445" @default.
- W230497445 workType "report" @default.