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• W2305106612 abstract "A new concept of semipermeable reservoirs containing co-cultures of cells and supporting microparticles is presented, inspired by the multi-phenotypic cellular environment of bone. Based on the deconstruction of the stem cell niche, the developed capsules are designed to drive a self-regulated osteogenesis. PLLA microparticles functionalized with collagen I, and a co-culture of adipose stem (ASCs) and endothelial (ECs) cells are immobilized in spherical liquified capsules. The capsules are coated with multilayers of poly(L-lysine), alginate, and chitosan nano-assembled through layer-by-layer. Capsules encapsulating ASCs alone or in a co-culture with ECs are cultured in endothelial medium with or without osteogenic differentiation factors. Results show that osteogenesis is enhanced by the co-encapsulation, which occurs even in the absence of differentiation factors. These findings are supported by an increased ALP activity and matrix mineralization, osteopontin detection, and the up regulation of BMP-2, RUNX2 and BSP. The liquified co-capsules also act as a VEGF and BMP-2 cytokines release system. The proposed liquified capsules might be a valuable injectable self-regulated system for bone regeneration employing highly translational cell sources." @default.
• W2305106612 created "2016-06-24" @default.
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• W2305106612 date "2016-02-24" @default.
• W2305106612 modified "2023-10-16" @default.
• W2305106612 title "Semipermeable Capsules Wrapping a Multifunctional and Self-regulated Co-culture Microenvironment for Osteogenic Differentiation" @default.
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• W2305106612 doi "https://doi.org/10.1038/srep21883" @default.
• W2305106612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764811" @default.
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• W2305106612 hasPublicationYear "2016" @default.
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