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- W2305113572 startingPage "8" @default.
- W2305113572 abstract "The recruitment of dental pulp stem cells (DPSC) is a prerequisite for the regeneration of dentin damaged by severe caries and/or mechanical injury. Understanding the complex process of DPSC recruitment will benefit future in situ tissue engineering applications based on the stimulation of endogenous DPSC for dentin pulp regeneration. The current known mobilization signals and subsequent migration of DPSC towards the lesion site, which is influenced by the pulp inflammatory state and the application of pulp capping materials, are reviewed. The research outcome of migration studies may be affected by the applied methodology, which should thus be chosen with care. Both the advantages and disadvantages of commonly used assays for investigating DPSC migration are discussed. This review highlights the fact that DPSC recruitment is dependent not only on the soluble chemotactic signals, but also on their interaction with neighboring cells and the extracellular matrix, which can be modified under pathological conditions. These are discussed to explain how these modifications lead to the stimulation of DPSC recruitment." @default.
- W2305113572 created "2016-06-24" @default.
- W2305113572 creator A5010521036 @default.
- W2305113572 creator A5031594309 @default.
- W2305113572 creator A5044418194 @default.
- W2305113572 creator A5082637880 @default.
- W2305113572 date "2016-03-25" @default.
- W2305113572 modified "2023-10-18" @default.
- W2305113572 title "Dental Pulp Stem Cell Recruitment Signals within Injured Dental Pulp Tissue" @default.
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- W2305113572 doi "https://doi.org/10.3390/dj4020008" @default.
- W2305113572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5851269" @default.