FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2305139664> ?p ?o ?g. }

• W2305139664 endingPage "861" @default.
• W2305139664 startingPage "856" @default.
• W2305139664 abstract "Hexasaccharide (HS) containing 3 U of cellobiuronic acid was isolated from Streptococcus pneumoniae type 3 capsular polysaccharide S3 and coupled to bovine serum albumin (BSA), keyhole limpet hemocyanin (KLH), or tetanus toxoid (TT). The immunogenicity of these HS-protein conjugates in BALB/c mice was studied by measuring the production of circulating antibodies and the induction of protective immunity to viable S. pneumoniae type 3. Immunization of BALB/c mice with 0.5 micrograms of S3 resulted in the induction of immunoglobulin M (IgM) antibodies and complete protection against 25 U of a mean lethal dose of S. pneumoniae type 3 for 19 weeks after immunization. BALB/c mice immunized with 100 micrograms of HS9-BSA (containing 12 micrograms of HS) were also protected due to circulating IgM antibodies. Repeated injections with either 100 micrograms of HS9-BSA (three immunizations) or 100 micrograms of HS6-KLH (two immunizations) resulted in high levels of circulating IgG antibodies. These HS-protein conjugates induced complete protection which lasted at least 14 (HS9-BSA), 23 (HS6-KLH), or 8 (HS16-TT) weeks after the last immunization. Protection against viable S. pneumoniae type 3 could be passively transferred to nonimmunized mice by antisera containing IgM or IgG antibodies or both. Sera containing both IgM and IgG antibodies gave better protection than sera containing only IgM antibodies. The specificity of the induced protection was confirmed by challenge with the non-cross-reacting S. pneumoniae type 11." @default.
• W2305139664 created "2016-06-24" @default.
• W2305139664 creator A5010200495 @default.
• W2305139664 creator A5049827050 @default.
• W2305139664 creator A5068797786 @default.
• W2305139664 creator A5069176120 @default.
• W2305139664 creator A5074868178 @default.
• W2305139664 creator A5076617781 @default.
• W2305139664 date "1983-06-01" @default.
• W2305139664 modified "2023-09-27" @default.
• W2305139664 title "Immunogenic properties in mice of hexasaccharide from the capsular polysaccharide of Streptococcus pneumoniae type 3" @default.
• W2305139664 cites W103470997 @default.
• W2305139664 cites W112859519 @default.
• W2305139664 cites W14088623 @default.
• W2305139664 cites W1515554307 @default.
• W2305139664 cites W1775749144 @default.
• W2305139664 cites W1777180563 @default.
• W2305139664 cites W1968834637 @default.
• W2305139664 cites W1977007850 @default.
• W2305139664 cites W1981804622 @default.
• W2305139664 cites W1985978067 @default.
• W2305139664 cites W1987459836 @default.
• W2305139664 cites W1994948666 @default.
• W2305139664 cites W2002731834 @default.
• W2305139664 cites W2022743246 @default.
• W2305139664 cites W2032799524 @default.
• W2305139664 cites W2040953363 @default.
• W2305139664 cites W2169253475 @default.
• W2305139664 cites W2194368740 @default.
• W2305139664 cites W2213361590 @default.
• W2305139664 cites W2313093393 @default.
• W2305139664 cites W4211104534 @default.
• W2305139664 doi "https://doi.org/10.1128/iai.40.3.856-861.1983" @default.
• W2305139664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/348130" @default.
• W2305139664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6852923" @default.
• W2305139664 hasPublicationYear "1983" @default.
• W2305139664 type Work @default.
• W2305139664 sameAs 2305139664 @default.
• W2305139664 citedByCount "40" @default.
• W2305139664 countsByYear W23051396642013 @default.
• W2305139664 countsByYear W23051396642016 @default.
• W2305139664 countsByYear W23051396642017 @default.
• W2305139664 countsByYear W23051396642018 @default.
• W2305139664 countsByYear W23051396642020 @default.
• W2305139664 crossrefType "journal-article" @default.
• W2305139664 hasAuthorship W2305139664A5010200495 @default.
• W2305139664 hasAuthorship W2305139664A5049827050 @default.
• W2305139664 hasAuthorship W2305139664A5068797786 @default.
• W2305139664 hasAuthorship W2305139664A5069176120 @default.
• W2305139664 hasAuthorship W2305139664A5074868178 @default.
• W2305139664 hasAuthorship W2305139664A5076617781 @default.
• W2305139664 hasBestOaLocation W23051396641 @default.
• W2305139664 hasConcept C147483822 @default.
• W2305139664 hasConcept C159654299 @default.
• W2305139664 hasConcept C203014093 @default.
• W2305139664 hasConcept C2776553844 @default.
• W2305139664 hasConcept C2776727803 @default.
• W2305139664 hasConcept C2777351567 @default.
• W2305139664 hasConcept C2779915011 @default.
• W2305139664 hasConcept C2780801004 @default.
• W2305139664 hasConcept C2780868878 @default.
• W2305139664 hasConcept C2780898057 @default.
• W2305139664 hasConcept C2781253189 @default.
• W2305139664 hasConcept C501593827 @default.
• W2305139664 hasConcept C86803240 @default.
• W2305139664 hasConcept C86807702 @default.
• W2305139664 hasConcept C89423630 @default.
• W2305139664 hasConcept C91523082 @default.
• W2305139664 hasConceptScore W2305139664C147483822 @default.
• W2305139664 hasConceptScore W2305139664C159654299 @default.
• W2305139664 hasConceptScore W2305139664C203014093 @default.
• W2305139664 hasConceptScore W2305139664C2776553844 @default.
• W2305139664 hasConceptScore W2305139664C2776727803 @default.
• W2305139664 hasConceptScore W2305139664C2777351567 @default.
• W2305139664 hasConceptScore W2305139664C2779915011 @default.
• W2305139664 hasConceptScore W2305139664C2780801004 @default.
• W2305139664 hasConceptScore W2305139664C2780868878 @default.
• W2305139664 hasConceptScore W2305139664C2780898057 @default.
• W2305139664 hasConceptScore W2305139664C2781253189 @default.
• W2305139664 hasConceptScore W2305139664C501593827 @default.
• W2305139664 hasConceptScore W2305139664C86803240 @default.
• W2305139664 hasConceptScore W2305139664C86807702 @default.
• W2305139664 hasConceptScore W2305139664C89423630 @default.
• W2305139664 hasConceptScore W2305139664C91523082 @default.
• W2305139664 hasIssue "3" @default.
• W2305139664 hasLocation W23051396641 @default.
• W2305139664 hasLocation W23051396642 @default.
• W2305139664 hasLocation W23051396643 @default.
• W2305139664 hasOpenAccess W2305139664 @default.
• W2305139664 hasPrimaryLocation W23051396641 @default.
• W2305139664 hasRelatedWork W115920532 @default.
• W2305139664 hasRelatedWork W1602183989 @default.
• W2305139664 hasRelatedWork W1611543608 @default.
• W2305139664 hasRelatedWork W1962151629 @default.
• W2305139664 hasRelatedWork W1978858659 @default.
• W2305139664 hasRelatedWork W2001148980 @default.
• W2305139664 hasRelatedWork W2065806719 @default.
• W2305139664 hasRelatedWork W2073023727 @default.

• next