FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2305217127> ?p ?o ?g. }

• W2305217127 endingPage "380" @default.
• W2305217127 startingPage "360" @default.
• W2305217127 abstract "We study a reduced continuous model describing the evolution of high grade gliomas in response to hypoxic events through the interplay of different cellular phenotypes. We show that hypoxic events, even when sporadic and/or limited in space, may have a crucial role on the acceleration of high grade gliomas growth. Our modeling approach is based on two cellular phenotypes. One of them is more migratory and a second one is more proliferative. Transitions between both phenotypes are driven by the local oxygen values, assumed in this simple model to be uniform. Surprisingly, even very localized in time hypoxia events leading to transient migratory populations have the potential to accelerate the tumor’s invasion speed up to speeds close to those of the migratory phenotype. The high invasion speed persists for times much longer than the lifetime of the hypoxic event. Moreover, the phenomenon is observed both when the migratory cells form a persistent wave of cells located on the invasion front and when they form a evanescent “ghost” wave disappearing after a short time by decay to the more proliferative phenotype. Our findings are obtained through numerical simulations of the model equations both in 1D and higher dimensional scenarios. We also provide a deeper mathematical analysis of some aspects of the problem such as the conditions for the existence of persistent waves of cells with a more migratory phenotype." @default.
• W2305217127 created "2016-06-24" @default.
• W2305217127 creator A5045145786 @default.
• W2305217127 creator A5060304932 @default.
• W2305217127 creator A5086382555 @default.
• W2305217127 date "2016-10-01" @default.
• W2305217127 modified "2023-10-18" @default.
• W2305217127 title "Nonlinear ghost waves accelerate the progression of high-grade brain tumors" @default.
• W2305217127 cites W1514578360 @default.
• W2305217127 cites W1560060148 @default.
• W2305217127 cites W1567827425 @default.
• W2305217127 cites W1965273403 @default.
• W2305217127 cites W1970295573 @default.
• W2305217127 cites W1970378385 @default.
• W2305217127 cites W1971593855 @default.
• W2305217127 cites W1975817152 @default.
• W2305217127 cites W1976578289 @default.
• W2305217127 cites W1978126680 @default.
• W2305217127 cites W1983769407 @default.
• W2305217127 cites W1985698425 @default.
• W2305217127 cites W1985911256 @default.
• W2305217127 cites W1990824001 @default.
• W2305217127 cites W1992478375 @default.
• W2305217127 cites W1993745402 @default.
• W2305217127 cites W1998166655 @default.
• W2305217127 cites W2011810742 @default.
• W2305217127 cites W2013945372 @default.
• W2305217127 cites W2014768395 @default.
• W2305217127 cites W2022451432 @default.
• W2305217127 cites W2023816651 @default.
• W2305217127 cites W2033987226 @default.
• W2305217127 cites W2036044314 @default.
• W2305217127 cites W2039075677 @default.
• W2305217127 cites W2045484383 @default.
• W2305217127 cites W2050855844 @default.
• W2305217127 cites W2055145844 @default.
• W2305217127 cites W2063331928 @default.
• W2305217127 cites W2071143412 @default.
• W2305217127 cites W2071948601 @default.
• W2305217127 cites W2074614782 @default.
• W2305217127 cites W2076500925 @default.
• W2305217127 cites W2079949023 @default.
• W2305217127 cites W2085724817 @default.
• W2305217127 cites W2088539970 @default.
• W2305217127 cites W2102488910 @default.
• W2305217127 cites W2110711017 @default.
• W2305217127 cites W2111967308 @default.
• W2305217127 cites W2117692326 @default.
• W2305217127 cites W2125109412 @default.
• W2305217127 cites W2132697290 @default.
• W2305217127 cites W2138088558 @default.
• W2305217127 cites W2143852804 @default.
• W2305217127 cites W2165754185 @default.
• W2305217127 cites W2167278625 @default.
• W2305217127 cites W2306611299 @default.
• W2305217127 cites W4297900680 @default.
• W2305217127 doi "https://doi.org/10.1016/j.cnsns.2016.03.014" @default.
• W2305217127 hasPublicationYear "2016" @default.
• W2305217127 type Work @default.
• W2305217127 sameAs 2305217127 @default.
• W2305217127 citedByCount "9" @default.
• W2305217127 countsByYear W23052171272014 @default.
• W2305217127 countsByYear W23052171272016 @default.
• W2305217127 countsByYear W23052171272017 @default.
• W2305217127 countsByYear W23052171272020 @default.
• W2305217127 countsByYear W23052171272023 @default.
• W2305217127 crossrefType "journal-article" @default.
• W2305217127 hasAuthorship W2305217127A5045145786 @default.
• W2305217127 hasAuthorship W2305217127A5060304932 @default.
• W2305217127 hasAuthorship W2305217127A5086382555 @default.
• W2305217127 hasBestOaLocation W23052171272 @default.
• W2305217127 hasConcept C104317684 @default.
• W2305217127 hasConcept C111919701 @default.
• W2305217127 hasConcept C121332964 @default.
• W2305217127 hasConcept C127716648 @default.
• W2305217127 hasConcept C134306372 @default.
• W2305217127 hasConcept C158622935 @default.
• W2305217127 hasConcept C2780799671 @default.
• W2305217127 hasConcept C2988173416 @default.
• W2305217127 hasConcept C33923547 @default.
• W2305217127 hasConcept C41008148 @default.
• W2305217127 hasConcept C540031477 @default.
• W2305217127 hasConcept C54355233 @default.
• W2305217127 hasConcept C62520636 @default.
• W2305217127 hasConcept C7836513 @default.
• W2305217127 hasConcept C86803240 @default.
• W2305217127 hasConceptScore W2305217127C104317684 @default.
• W2305217127 hasConceptScore W2305217127C111919701 @default.
• W2305217127 hasConceptScore W2305217127C121332964 @default.
• W2305217127 hasConceptScore W2305217127C127716648 @default.
• W2305217127 hasConceptScore W2305217127C134306372 @default.
• W2305217127 hasConceptScore W2305217127C158622935 @default.
• W2305217127 hasConceptScore W2305217127C2780799671 @default.
• W2305217127 hasConceptScore W2305217127C2988173416 @default.
• W2305217127 hasConceptScore W2305217127C33923547 @default.
• W2305217127 hasConceptScore W2305217127C41008148 @default.
• W2305217127 hasConceptScore W2305217127C540031477 @default.
• W2305217127 hasConceptScore W2305217127C54355233 @default.

• next