Matches in SemOpenAlex for { <https://semopenalex.org/work/W2305285206> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2305285206 endingPage "F537" @default.
- W2305285206 startingPage "F530" @default.
- W2305285206 abstract "Monolayers of the porcine-derived renal epithelial cell line, LLC-PK1, were used to characterize the effects of heat stress on Na+-glucose cotransport. Transepithelial current dependent on 5 mM glucose (I(Glc)), phloridzin-sensitive current (I(phz)), and total transepithelial current (I(total)) were measured as indicators of Na+-glucose cotransport. Severe heat shock (SHS; 45 degrees C for 1 h, then 37 degrees C for measurements) decreased transepithelial electrical resistance (TER), I(Glc), I(phz), and I(total) 50-70%. Mild heat shock (MHS; 42 degrees C for 3 h, then 37 degrees C for 12 h) induced accumulation of 72-kDa heat shock protein (HSP-72), decreased damage to TER from SHS, and prevented damage to I(Glc), I(phz), and I(total). Kinetic analysis showed that SHS damaged and MHS protected total Na+-glucose transport capacity (Vmax of I(Glc)). MHS alone increased TER (50%), I(Glc) (20%), I(total) (20%), and Vmax of I(Glc) (25%). On enhancement of the Na+ gradient by depletion of intracellular Na+, MHS increased I(Glc) 50% and had no effect on transepithelial Na+-dependent sulfate reabsorptive flux measured concurrently or in Na+-replete tissues. These effects of MHS were not reflected in effects on cell survival or luminal membrane surface area as indicated by lactate dehydrogenase or alkaline phosphatase release. In conclusion, HSP-72-inducing heat treatment both protected and enhanced Na+-glucose cotransport independently of the luminal membrane Na+ gradient and selectively with respect to effects on TER, reabsorptive sulfate transport, cell survival, and luminal membrane surface area." @default.
- W2305285206 created "2016-06-24" @default.
- W2305285206 creator A5069523878 @default.
- W2305285206 creator A5087729174 @default.
- W2305285206 date "1997-10-01" @default.
- W2305285206 modified "2023-09-27" @default.
- W2305285206 title "Heat shock-induced protection and enhancement of Na<sup>+</sup>-glucose cotransport by LLC-PK<sub>1</sub>monolayers" @default.
- W2305285206 cites W1538763799 @default.
- W2305285206 cites W1544647282 @default.
- W2305285206 cites W1566451495 @default.
- W2305285206 cites W1983364877 @default.
- W2305285206 cites W2012333825 @default.
- W2305285206 cites W2030485204 @default.
- W2305285206 cites W2042188303 @default.
- W2305285206 cites W2045865115 @default.
- W2305285206 cites W2046126235 @default.
- W2305285206 cites W2051002291 @default.
- W2305285206 cites W2060071007 @default.
- W2305285206 cites W2071277783 @default.
- W2305285206 cites W2073347694 @default.
- W2305285206 cites W2073477794 @default.
- W2305285206 cites W2079321385 @default.
- W2305285206 cites W2093443865 @default.
- W2305285206 cites W2100837269 @default.
- W2305285206 cites W2110586785 @default.
- W2305285206 cites W2115169777 @default.
- W2305285206 cites W2132034903 @default.
- W2305285206 cites W2230427843 @default.
- W2305285206 cites W2253612889 @default.
- W2305285206 cites W2327804919 @default.
- W2305285206 cites W2338117247 @default.
- W2305285206 cites W2472808866 @default.
- W2305285206 doi "https://doi.org/10.1152/ajprenal.1997.273.4.f530" @default.
- W2305285206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9362330" @default.
- W2305285206 hasPublicationYear "1997" @default.
- W2305285206 type Work @default.
- W2305285206 sameAs 2305285206 @default.
- W2305285206 citedByCount "7" @default.
- W2305285206 countsByYear W23052852062013 @default.
- W2305285206 countsByYear W23052852062020 @default.
- W2305285206 countsByYear W23052852062021 @default.
- W2305285206 crossrefType "journal-article" @default.
- W2305285206 hasAuthorship W2305285206A5069523878 @default.
- W2305285206 hasAuthorship W2305285206A5087729174 @default.
- W2305285206 hasConcept C12554922 @default.
- W2305285206 hasConcept C134018914 @default.
- W2305285206 hasConcept C161573976 @default.
- W2305285206 hasConcept C178790620 @default.
- W2305285206 hasConcept C181199279 @default.
- W2305285206 hasConcept C185592680 @default.
- W2305285206 hasConcept C188053792 @default.
- W2305285206 hasConcept C2777318727 @default.
- W2305285206 hasConcept C2779306644 @default.
- W2305285206 hasConcept C537181965 @default.
- W2305285206 hasConcept C55493867 @default.
- W2305285206 hasConcept C79879829 @default.
- W2305285206 hasConcept C86803240 @default.
- W2305285206 hasConceptScore W2305285206C12554922 @default.
- W2305285206 hasConceptScore W2305285206C134018914 @default.
- W2305285206 hasConceptScore W2305285206C161573976 @default.
- W2305285206 hasConceptScore W2305285206C178790620 @default.
- W2305285206 hasConceptScore W2305285206C181199279 @default.
- W2305285206 hasConceptScore W2305285206C185592680 @default.
- W2305285206 hasConceptScore W2305285206C188053792 @default.
- W2305285206 hasConceptScore W2305285206C2777318727 @default.
- W2305285206 hasConceptScore W2305285206C2779306644 @default.
- W2305285206 hasConceptScore W2305285206C537181965 @default.
- W2305285206 hasConceptScore W2305285206C55493867 @default.
- W2305285206 hasConceptScore W2305285206C79879829 @default.
- W2305285206 hasConceptScore W2305285206C86803240 @default.
- W2305285206 hasIssue "4" @default.
- W2305285206 hasLocation W23052852061 @default.
- W2305285206 hasLocation W23052852062 @default.
- W2305285206 hasOpenAccess W2305285206 @default.
- W2305285206 hasPrimaryLocation W23052852061 @default.
- W2305285206 hasRelatedWork W1984579875 @default.
- W2305285206 hasRelatedWork W2017968105 @default.
- W2305285206 hasRelatedWork W2021773990 @default.
- W2305285206 hasRelatedWork W2070839508 @default.
- W2305285206 hasRelatedWork W2089185841 @default.
- W2305285206 hasRelatedWork W2146560262 @default.
- W2305285206 hasRelatedWork W2154012993 @default.
- W2305285206 hasRelatedWork W2154919270 @default.
- W2305285206 hasRelatedWork W2410044991 @default.
- W2305285206 hasRelatedWork W2416630674 @default.
- W2305285206 hasVolume "273" @default.
- W2305285206 isParatext "false" @default.
- W2305285206 isRetracted "false" @default.
- W2305285206 magId "2305285206" @default.
- W2305285206 workType "article" @default.