Matches in SemOpenAlex for { <https://semopenalex.org/work/W2305458210> ?p ?o ?g. }
- W2305458210 endingPage "851" @default.
- W2305458210 startingPage "837" @default.
- W2305458210 abstract "Introduction: Lung cancer still represents the leading cause of death for cancer. About the 70% of diagnosis are in advanced-stage. Non-small-cell lung cancer (NSCLC) represents the 85% of all diagnosed lung cancers and non-squamous histology represents the 40% of all NSCLC. First-line therapies increase survival, control symptoms and improve quality of life, compared with best supportive care. It is crucial to choose a treatment with a low impact on patient’s life considering the related toxicities.Areas covered: Adverse events (AEs) of first-line therapies for non-squamous NSCLC are here reviewed and discussed, from evidences in clinical trials conducting to drugs approval.Expert opinion: For advanced disease, palliation and preserving patients QoL are still the primary goal of treatment. Therefore, differing toxicity profiles are often a deciding factor in first-line and also maintenance setting for non-squamous NSCLC.Special attention is necessary to renal function and drugs’ nephrotoxicity. Moreover, it is to consider the specific AEs of drugs classes: hypertension, bleeding, and proteinuria, for anti-VEGF therapy; skin toxicity, diarrhea, interstitial lung disease for TKIs; vision disorders, and hepatotoxicity for ALK-inhibitor. It is important to select patients for a treatment on the basis of their comorbidities and the presence of risk factors." @default.
- W2305458210 created "2016-06-24" @default.
- W2305458210 creator A5020987606 @default.
- W2305458210 creator A5045384053 @default.
- W2305458210 date "2016-04-12" @default.
- W2305458210 modified "2023-09-27" @default.
- W2305458210 title "Safety profiles of first-line therapies for metastatic non-squamous non-small-cell lung cancer" @default.
- W2305458210 cites W1493453469 @default.
- W2305458210 cites W1521544422 @default.
- W2305458210 cites W158971313 @default.
- W2305458210 cites W1924428325 @default.
- W2305458210 cites W1964922874 @default.
- W2305458210 cites W1969914656 @default.
- W2305458210 cites W1970299210 @default.
- W2305458210 cites W1974903221 @default.
- W2305458210 cites W1974903851 @default.
- W2305458210 cites W1982379324 @default.
- W2305458210 cites W1985329793 @default.
- W2305458210 cites W1988827171 @default.
- W2305458210 cites W1989254456 @default.
- W2305458210 cites W1991600912 @default.
- W2305458210 cites W2003701831 @default.
- W2305458210 cites W2005244154 @default.
- W2305458210 cites W2010619956 @default.
- W2305458210 cites W2024492396 @default.
- W2305458210 cites W2025401151 @default.
- W2305458210 cites W2037139573 @default.
- W2305458210 cites W2040253672 @default.
- W2305458210 cites W2043696829 @default.
- W2305458210 cites W2050249255 @default.
- W2305458210 cites W2052016211 @default.
- W2305458210 cites W2055402151 @default.
- W2305458210 cites W2063171301 @default.
- W2305458210 cites W2063312867 @default.
- W2305458210 cites W2063391304 @default.
- W2305458210 cites W2073979951 @default.
- W2305458210 cites W2077383408 @default.
- W2305458210 cites W2080790753 @default.
- W2305458210 cites W2080992857 @default.
- W2305458210 cites W2084139473 @default.
- W2305458210 cites W2092536220 @default.
- W2305458210 cites W2096198395 @default.
- W2305458210 cites W2099530756 @default.
- W2305458210 cites W2099556905 @default.
- W2305458210 cites W2099725888 @default.
- W2305458210 cites W2100785570 @default.
- W2305458210 cites W2100912832 @default.
- W2305458210 cites W2101329867 @default.
- W2305458210 cites W2102627969 @default.
- W2305458210 cites W2104830962 @default.
- W2305458210 cites W2111662961 @default.
- W2305458210 cites W2112362471 @default.
- W2305458210 cites W2112621029 @default.
- W2305458210 cites W2120718661 @default.
- W2305458210 cites W2122553809 @default.
- W2305458210 cites W2122712858 @default.
- W2305458210 cites W2122798232 @default.
- W2305458210 cites W2125735484 @default.
- W2305458210 cites W2125760261 @default.
- W2305458210 cites W2126090721 @default.
- W2305458210 cites W2128002599 @default.
- W2305458210 cites W2128082578 @default.
- W2305458210 cites W2129360604 @default.
- W2305458210 cites W2130488043 @default.
- W2305458210 cites W2132157071 @default.
- W2305458210 cites W2132870547 @default.
- W2305458210 cites W2134061119 @default.
- W2305458210 cites W2134667653 @default.
- W2305458210 cites W2134787029 @default.
- W2305458210 cites W2136601558 @default.
- W2305458210 cites W2138297714 @default.
- W2305458210 cites W2138851777 @default.
- W2305458210 cites W2144239186 @default.
- W2305458210 cites W2144648936 @default.
- W2305458210 cites W2144660856 @default.
- W2305458210 cites W2145835533 @default.
- W2305458210 cites W2148367564 @default.
- W2305458210 cites W2150424194 @default.
- W2305458210 cites W2151620138 @default.
- W2305458210 cites W2154442955 @default.
- W2305458210 cites W2154581953 @default.
- W2305458210 cites W2154662831 @default.
- W2305458210 cites W2155338842 @default.
- W2305458210 cites W2156438240 @default.
- W2305458210 cites W2160336497 @default.
- W2305458210 cites W2160982674 @default.
- W2305458210 cites W2166084034 @default.
- W2305458210 cites W2167191456 @default.
- W2305458210 cites W2171139285 @default.
- W2305458210 cites W2184779060 @default.
- W2305458210 cites W2460871368 @default.
- W2305458210 cites W2917837889 @default.
- W2305458210 doi "https://doi.org/10.1517/14740338.2016.1170116" @default.
- W2305458210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27007279" @default.
- W2305458210 hasPublicationYear "2016" @default.
- W2305458210 type Work @default.
- W2305458210 sameAs 2305458210 @default.
- W2305458210 citedByCount "12" @default.