FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2305592025> ?p ?o ?g. }

• W2305592025 abstract "Low-molecular mass natural products from bacteria, fungi, plants and marine organisms exhibit unique structural diversity which are of interest for the identification of new lead structures for medicinals and agrochemicals. In the search for bioactive compounds from marine sponges and sponge-associated fungi, this research work resulted to the isolation of twenty-six compounds, eight of which are new metabolites. The sponges were collected from the Indo-pacific regions, particularly those from Indonesian and Philippine waters, as well as those from the Mediterranean Sea near the island of Elba in Italy. A combination of the chemically- and biologically-driven approach for drug discovery was employed, wherein extracts were screened for antibacterial, antifungal and cytotoxic activities. In addition to the bioassay-guided approach to purify the compounds responsible for the activity of the extract, TLC, UV and MS were also used to isolate the chemically most interesting substances. Hence, purified compounds which are not responsible for the initial bioscreening activity may have a chance to be evaluated for other bioactivities. Enumerated below are the compounds which have been isolated and structurally elucidated and whose bioactivities have been further characterized. 1. The extract of the fungus Cladosporium herbarum associated with the sponge Callyspongia aerizusa afforded seven structurally related polyketides, including two new twelve-membered macrolides: pandangolide 3 and 4, and a new acetyl congener of the previously isolated 5-hydroxymethyl-2-furoic acid. The two furoic acid analogues isolated were found to be responsible for the antimicrobial activity of the extract. The isolation of the known phytotoxin Cladospolide B from Cladosporium herbarum, which was originally known from Cladosporium cladosporioides and C. tenuissimum, indicates the possibility that Cladospolide B may be a chemotaxonomic marker of particular Cladosporium species. 2. The extract of the fungus Curvularia lunata associated with the Indonesian sponge Niphates olemda yielded three compounds, namely the new antimicrobially-active anthraquinone lunatin, the known bisanthraquinone cytoskyrin A, and the known plant hormone abscisic acid. The co-occurrence of the two structurally-related anthraquinones suggests that the monomeric lunatin may be a precursor in the biosynthesis of the bisanthraquinone cytoskyrin A. 3. The fungus Penicillium spp. associated with the Mediterranean sponge Axinella verrucosa yielded six compounds, namely the known antifungal griseofulvin and its less active dechloro analogue; the known toxin oxaline; and the known cytotoxic metabolite communesin B and its two new congeners communesin C and D. The new communesins were less active than communesin B in the brine-shrimp lethality test. 4. An unidentified fungus which was also isolated from the same Mediterranean sponge Axinella verrucosa as Penicillium spp. yielded the known compound monocerin which has been reported to possess phytotoxic and insecticidal activities. 5. The fungus Aspergillus flavus associated with the Philippine sponge Hyrtios aff. reticulatus yielded the known toxin a-cyclopiazonic acid. 6. The Indonesian sponge Agelas nakamurai yielded four bromopyrrole alkaloids namely the new compound 4-bromo-pyrrole-2-carboxylic acid, and the known compounds: 4-bromo-pyrrole-2-carboxamide, mukanadin B and mukanadin C. All of the four compounds except mukanadin B were found to be antimicrobially-active. Bromopyrrole alkaloids are well-known metabolites of the genus Agelas and are proven to play an important role in the chemical defense of the sponge against predation from fishes. 7. The Indonesian sponge Jaspis splendens yielded three known substances which are known for their antiproliferative activities, namely the depsipeptides jaspamide (jasplakinolide), and its derivatives jaspamide B and jaspamide C." @default.
• W2305592025 created "2016-06-24" @default.
• W2305592025 creator A5006465030 @default.
• W2305592025 date "2002-01-01" @default.
• W2305592025 modified "2023-09-23" @default.
• W2305592025 title "Isolation and structure elucidation of bioactive secondary metabolites from marine sponges and sponge-derived fungi" @default.
• W2305592025 cites W132469279 @default.
• W2305592025 cites W1415062607 @default.
• W2305592025 cites W1495350538 @default.
• W2305592025 cites W1528021834 @default.
• W2305592025 cites W1533505882 @default.
• W2305592025 cites W1564127063 @default.
• W2305592025 cites W1606965631 @default.
• W2305592025 cites W1643594504 @default.
• W2305592025 cites W1673924 @default.
• W2305592025 cites W1963543726 @default.
• W2305592025 cites W1964467373 @default.
• W2305592025 cites W1964896185 @default.
• W2305592025 cites W1965451446 @default.
• W2305592025 cites W1966124873 @default.
• W2305592025 cites W1968147419 @default.
• W2305592025 cites W1969768462 @default.
• W2305592025 cites W1972857133 @default.
• W2305592025 cites W1974573831 @default.
• W2305592025 cites W1974977395 @default.
• W2305592025 cites W1975292318 @default.
• W2305592025 cites W1975559070 @default.
• W2305592025 cites W1977198215 @default.
• W2305592025 cites W1980596953 @default.
• W2305592025 cites W1980777630 @default.
• W2305592025 cites W1980842518 @default.
• W2305592025 cites W1981880424 @default.
• W2305592025 cites W1983170834 @default.
• W2305592025 cites W1983689954 @default.
• W2305592025 cites W1984039620 @default.
• W2305592025 cites W1985529148 @default.
• W2305592025 cites W1987155854 @default.
• W2305592025 cites W1987964225 @default.
• W2305592025 cites W1989251420 @default.
• W2305592025 cites W1992154547 @default.
• W2305592025 cites W1994782926 @default.
• W2305592025 cites W1995460460 @default.
• W2305592025 cites W1996091550 @default.
• W2305592025 cites W2001503803 @default.
• W2305592025 cites W2006930818 @default.
• W2305592025 cites W2013994536 @default.
• W2305592025 cites W2014394645 @default.
• W2305592025 cites W2016750891 @default.
• W2305592025 cites W2016998310 @default.
• W2305592025 cites W2017553996 @default.
• W2305592025 cites W2023091176 @default.
• W2305592025 cites W2023528999 @default.
• W2305592025 cites W2023564082 @default.
• W2305592025 cites W2023741737 @default.
• W2305592025 cites W2025613912 @default.
• W2305592025 cites W2025736883 @default.
• W2305592025 cites W2025956394 @default.
• W2305592025 cites W2025999444 @default.
• W2305592025 cites W2027104341 @default.
• W2305592025 cites W2029316232 @default.
• W2305592025 cites W2031793205 @default.
• W2305592025 cites W2031863617 @default.
• W2305592025 cites W2035050863 @default.
• W2305592025 cites W2038458102 @default.
• W2305592025 cites W2038502875 @default.
• W2305592025 cites W2038739450 @default.
• W2305592025 cites W2039180534 @default.
• W2305592025 cites W2041886814 @default.
• W2305592025 cites W2041982134 @default.
• W2305592025 cites W2042917595 @default.
• W2305592025 cites W2043843360 @default.
• W2305592025 cites W2045129223 @default.
• W2305592025 cites W2049443929 @default.
• W2305592025 cites W2053845725 @default.
• W2305592025 cites W2055727374 @default.
• W2305592025 cites W2056441395 @default.
• W2305592025 cites W2057993014 @default.
• W2305592025 cites W2058872358 @default.
• W2305592025 cites W2060230135 @default.
• W2305592025 cites W2060406170 @default.
• W2305592025 cites W2061248267 @default.
• W2305592025 cites W2064756624 @default.
• W2305592025 cites W2067278945 @default.
• W2305592025 cites W2067631039 @default.
• W2305592025 cites W2071470938 @default.
• W2305592025 cites W2072133690 @default.
• W2305592025 cites W2074509460 @default.
• W2305592025 cites W2074836458 @default.
• W2305592025 cites W2074894987 @default.
• W2305592025 cites W2078975653 @default.
• W2305592025 cites W2079221614 @default.
• W2305592025 cites W2079258852 @default.
• W2305592025 cites W2081225806 @default.
• W2305592025 cites W2084642908 @default.
• W2305592025 cites W2084997068 @default.
• W2305592025 cites W2086544714 @default.
• W2305592025 cites W2087952402 @default.
• W2305592025 cites W2090400653 @default.
• W2305592025 cites W2090519212 @default.
• W2305592025 cites W2092109915 @default.

• next