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- W2305933761 abstract "The impact of extended-spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (PMAβs) of animal origin constitutes a public health concern. In this study, 179 Escherichia coli from food animals and products were analyzed, among which, 15 cephalosporin-resistant isolates harboring ESBL (CTX-M-1 [n = 8], CTX-M-14 [n = 1], SHV-12 [n = 2]) or PMAβ [CMY-2, n = 5]) were identified in poultry and swine, from different farms of distinct regions of Portugal. The multiple sequence-type IncI1-driven spread of ESBLs and PMAβs, flanked by widely disseminated mobile elements, was guaranteed by ST26/IncI1-harboring blaSHV-12, ST12/IncI1-harboring blaCMY-2, ST3 and ST38/IncI1-harboring blaCTX-M-1, and ST1/IncI1-harboring blaCTX-M-14. An IS10-disrupted In2-4, presenting a new attI2 recombination site, was also detected in a SHV-12/CTX-M-1-harboring isolate. This study highlights the fact that animals may act as persistent sources of ESBL- and PMAβ-harboring plasmids genes that might be transferred to humans through direct contact or via the food chain." @default.
- W2305933761 created "2016-06-24" @default.
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- W2305933761 date "2016-01-01" @default.
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- W2305933761 title "New Class 2 Integron In<i>2-4</i> Among IncI1-Positive <i>Escherichia coli</i> Isolates Carrying ESBL and PMAβ Genes from Food Animals in Portugal" @default.
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- W2305933761 doi "https://doi.org/10.1089/fpd.2015.1972" @default.
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