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• W2306070227 endingPage "1107" @default.
• W2306070227 startingPage "1098" @default.
• W2306070227 abstract "Abstract Introduction Tau immunotherapy has emerged as a promising approach to clear tau aggregates from the brain. Our previous findings suggest that tau antibodies may act outside and within neurons to promote such clearance. Methods We have developed an approach using flow cytometry, a human neuroblastoma cell model overexpressing tau with the P301L mutation, and paired helical filament (PHF)–enriched pathologic tau to effectively screen uptake and retention of tau antibodies in conjunction with PHF. Results The flow cytometry approach correlates well with Western blot analysis to detect internalized antibodies in naïve and transfected SH‐SY5Y cells (r 2 = 0.958, and r 2 = 0.968, P = .021 and P = .016, respectively). In transfected cells, more antibodies are taken up/retained as pathologic tau load increases, both under co‐treated conditions and when the cells are pretreated with PHF before antibody administration (r 2 = 0.999 and r 2 = 0.999, P = .013 and P = .011, respectively). Discussion This approach allows rapid in vitro screening of antibody uptake and retention in conjunction with pathologic tau protein before more detailed studies in animals or other more complex model systems." @default.
• W2306070227 created "2016-06-24" @default.
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• W2306070227 date "2016-03-22" @default.
• W2306070227 modified "2023-10-12" @default.
• W2306070227 title "Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach" @default.
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• W2306070227 doi "https://doi.org/10.1016/j.jalz.2016.01.013" @default.
• W2306070227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5383206" @default.
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