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• W2306282013 startingPage "1439" @default.
• W2306282013 abstract "The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay system. HPR1 is a gene that is in single copy on chromosome IV of Saccharomyces cerevisiae, closely linked to ARO1, and it codes for a putative protein of 752 amino acids (molecular mass, 88 kilodaltons). Computer searches revealed homology (48.8% conserved homology; 24.8% identity) with the S. cerevisiae TOP1 gene in an alpha-helical stretch of 129 amino acids near the carboxy-terminal region of both proteins. The ethyl methanesulfonate-induced hpr1-1 mutation is a single-base change that produces a stop codon at amino acid 559 coding for a protein that lacks the carboxy-terminal TOP1 homologous region. Haploid strains carrying deletions of the HPR1 gene show a slightly reduced mitotic growth rate and extremely high rates of intrachromosomal excision recombination (frequency, 10 to 15%) but have a undetectable effect on rDNA recombination. Double-null mutants hpr1 top1 grow very poorly. We conclude that Hpr1 is a novel eucaryotic protein, mutation of which causes an increase in mitotic intrachromosomal excision recombination, and that it may be functionally related to an activity of the topoisomerase I protein." @default.
• W2306282013 created "2016-06-24" @default.
• W2306282013 creator A5043281613 @default.
• W2306282013 creator A5074023767 @default.
• W2306282013 date "1990-04-01" @default.
• W2306282013 modified "2023-09-24" @default.
• W2306282013 title "HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene." @default.
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• W2306282013 doi "https://doi.org/10.1128/mcb.10.4.1439" @default.
• W2306282013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/362246" @default.
• W2306282013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2181275" @default.
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