FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2306594920> ?p ?o ?g. }

• W2306594920 endingPage "e0151901" @default.
• W2306594920 startingPage "e0151901" @default.
• W2306594920 abstract "Background Breast cancer is reported to cause the highest mortality among female cancer patients. Previous studies have explored the association of silent mating-type information regulator 2 homolog 1 (SIRT1) gene expression with prognosis in breast cancer. However, no studies exist, so far, on the role of SIRT1 gene polymorphism in breast cancer risk or prognosis. The present study aimed to assess the association between SIRT1 gene polymorphisms and breast cancer in Egyptians. Methods The study comprised 980 Egyptian females divided into a breast cancer group (541 patients) and a healthy control group (439 subjects). SIRT1 gene single nucleotide polymorphisms (SNPs) rs3758391, rs3740051 and rs12778366 were genotyped using real-time polymerase chain reaction (RT-PCR). Allelic and genotypic frequencies were determined in both groups and association with breast cancer and clinicopathological characteristics was assessed. Results Breast cancer patients exhibited elevated serum SIRT1 levels which varied among different tumor grades. SIRT1 rs3758391 and rs12778366 TT genotypes were more frequent, exhibited higher SIRT1 levels than CC and CT genotypes and were associated with histologic grade and lymph node status. SIRT1 rs12778366 TT genotype also correlated with negative estrogen receptor (ER) and progesterone receptor (PR) statuses. The T allele frequency for both SNPs was higher in breast cancer patients than in normal subjects. Combined GG and AG genotypes of rs3740051 were more frequent, showed higher serum SIRT1 levels than the AA genotype, and were associated with ER and PR expression. Furthermore, inheritance of the G allele was associated with breast cancer. Conclusions Our findings reveal that rs3758391 and rs12778366 polymorphisms of SIRT1 gene are associated with breast cancer risk and prognosis in the Egyptian population." @default.
• W2306594920 created "2016-06-24" @default.
• W2306594920 creator A5011440961 @default.
• W2306594920 creator A5027349050 @default.
• W2306594920 creator A5060361437 @default.
• W2306594920 date "2016-03-21" @default.
• W2306594920 modified "2023-10-17" @default.
• W2306594920 title "Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians" @default.
• W2306594920 cites W1599071048 @default.
• W2306594920 cites W1870790255 @default.
• W2306594920 cites W1963554273 @default.
• W2306594920 cites W1974113113 @default.
• W2306594920 cites W1976727919 @default.
• W2306594920 cites W1984073962 @default.
• W2306594920 cites W1985349463 @default.
• W2306594920 cites W1989236302 @default.
• W2306594920 cites W1992207445 @default.
• W2306594920 cites W1996010157 @default.
• W2306594920 cites W2002418205 @default.
• W2306594920 cites W2008931918 @default.
• W2306594920 cites W2009648073 @default.
• W2306594920 cites W2012085460 @default.
• W2306594920 cites W2021241462 @default.
• W2306594920 cites W202300470 @default.
• W2306594920 cites W2024786674 @default.
• W2306594920 cites W2029868343 @default.
• W2306594920 cites W2030447006 @default.
• W2306594920 cites W2037723157 @default.
• W2306594920 cites W2038567829 @default.
• W2306594920 cites W2040284168 @default.
• W2306594920 cites W2042818066 @default.
• W2306594920 cites W2043661576 @default.
• W2306594920 cites W2043904036 @default.
• W2306594920 cites W2044784487 @default.
• W2306594920 cites W2050363846 @default.
• W2306594920 cites W2056069695 @default.
• W2306594920 cites W2057317668 @default.
• W2306594920 cites W2066605494 @default.
• W2306594920 cites W2078901327 @default.
• W2306594920 cites W2080192652 @default.
• W2306594920 cites W2092728526 @default.
• W2306594920 cites W2106787323 @default.
• W2306594920 cites W2113222880 @default.
• W2306594920 cites W2120526866 @default.
• W2306594920 cites W2123731635 @default.
• W2306594920 cites W2137765887 @default.
• W2306594920 cites W2140625809 @default.
• W2306594920 cites W2146143823 @default.
• W2306594920 cites W2154202727 @default.
• W2306594920 cites W2155222693 @default.
• W2306594920 cites W2155972116 @default.
• W2306594920 cites W2158440166 @default.
• W2306594920 cites W2159711144 @default.
• W2306594920 cites W2163435127 @default.
• W2306594920 cites W2166129732 @default.
• W2306594920 cites W2263023695 @default.
• W2306594920 cites W2320106881 @default.
• W2306594920 cites W4231018668 @default.
• W2306594920 cites W4234081105 @default.
• W2306594920 doi "https://doi.org/10.1371/journal.pone.0151901" @default.
• W2306594920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4801365" @default.
• W2306594920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26999517" @default.
• W2306594920 hasPublicationYear "2016" @default.
• W2306594920 type Work @default.
• W2306594920 sameAs 2306594920 @default.
• W2306594920 citedByCount "22" @default.
• W2306594920 countsByYear W23065949202016 @default.
• W2306594920 countsByYear W23065949202017 @default.
• W2306594920 countsByYear W23065949202018 @default.
• W2306594920 countsByYear W23065949202019 @default.
• W2306594920 countsByYear W23065949202020 @default.
• W2306594920 countsByYear W23065949202021 @default.
• W2306594920 countsByYear W23065949202022 @default.
• W2306594920 crossrefType "journal-article" @default.
• W2306594920 hasAuthorship W2306594920A5011440961 @default.
• W2306594920 hasAuthorship W2306594920A5027349050 @default.
• W2306594920 hasAuthorship W2306594920A5060361437 @default.
• W2306594920 hasBestOaLocation W23065949201 @default.
• W2306594920 hasConcept C104317684 @default.
• W2306594920 hasConcept C121608353 @default.
• W2306594920 hasConcept C126322002 @default.
• W2306594920 hasConcept C135763542 @default.
• W2306594920 hasConcept C143998085 @default.
• W2306594920 hasConcept C146304588 @default.
• W2306594920 hasConcept C153209595 @default.
• W2306594920 hasConcept C180754005 @default.
• W2306594920 hasConcept C37463918 @default.
• W2306594920 hasConcept C530470458 @default.
• W2306594920 hasConcept C54355233 @default.
• W2306594920 hasConcept C71924100 @default.
• W2306594920 hasConcept C84606932 @default.
• W2306594920 hasConcept C86803240 @default.
• W2306594920 hasConceptScore W2306594920C104317684 @default.
• W2306594920 hasConceptScore W2306594920C121608353 @default.
• W2306594920 hasConceptScore W2306594920C126322002 @default.
• W2306594920 hasConceptScore W2306594920C135763542 @default.
• W2306594920 hasConceptScore W2306594920C143998085 @default.
• W2306594920 hasConceptScore W2306594920C146304588 @default.

• next