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- W2306688460 abstract "It is over several decades that ultrasound is used to enhance the transdermal drug delivery (phonphoresis). The mechanism of the e nhancement is not fully understood and the ability of ultrasound on the enhancement for some drugs is unclear. The effect of continuous wave 870 KHz ultrasound at i ntensity of 1 W/cm 2 for 15 minutes on transdermal absorption of piroxicam from solution and gel formulations in hai rless rat skin was studied. Exposure to ultrasound increased the rate of diffusion from gel and solution of piroxicam to 10 and 3 times higher than that in skins not exposed to ultrasound. We strongly believe that the lower diffusion of piroxicam from the solution is caused by extra -bubbles generated by ultrasound. It can be suggested that cavitation activity and its negative surface charges play a dominant" @default.
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- W2306688460 date "2008-01-01" @default.
- W2306688460 modified "2023-09-27" @default.
- W2306688460 title "THE EFFECT OF BUBBLE SURFACE CHARGE ON PHONOPHORESIS: IMPLICATION IN TRANSDERMAL PIROXICAM DELIVERY" @default.
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