Matches in SemOpenAlex for { <https://semopenalex.org/work/W2306937125> ?p ?o ?g. }
- W2306937125 endingPage "6" @default.
- W2306937125 startingPage "1150" @default.
- W2306937125 abstract "Caffeine and 7,8-benzoflavone activate CYP3A2 in rat liver microsomes. Both activators appear to enhance enzyme activity by an increase in Vmax and to a lesser extent a decrease in Km. Additive effect studies demonstrated that the two activators oppose one another's effect. Electron transfer steps in the cytochrome P450 cycle are involved in the mechanism of cytochrome P450 activation, as indicated by the lack of effect of caffeine or 7,8-benzoflavone on cumene hydroperoxide-supported oxidation of acetaminophen by cytochrome P450. The involvement of cytochrome b5 in the formation of N-acetyl-p-benzoquinone imine (NAPQI) was implicated through a synergistic effect of NADH on the NADPH-supported reaction. Anti-cytochrome b5, but not anti-cytochrome P450 reductase IgG, diminished the activation effect of caffeine on NAPQI formation. Neither antibody altered the effect of 7,8-benzoflavone on NAPQI formation. The impairment of NAPQI formation by cytochrome b5 antibody suggests that cytochrome P450 activation by caffeine but not 7,8-benzoflavone is mediated in part through enhancement of the transfer of the second electron to cytochrome P450 from cytochrome b5." @default.
- W2306937125 created "2016-06-24" @default.
- W2306937125 creator A5004489015 @default.
- W2306937125 creator A5050017752 @default.
- W2306937125 creator A5059001915 @default.
- W2306937125 creator A5061422874 @default.
- W2306937125 creator A5087288886 @default.
- W2306937125 date "1997-10-01" @default.
- W2306937125 modified "2023-09-29" @default.
- W2306937125 title "Mechanism of cytochrome P450 activation by caffeine and 7,8-benzoflavone in rat liver microsomes." @default.
- W2306937125 cites W105949446 @default.
- W2306937125 cites W1506421347 @default.
- W2306937125 cites W1578271139 @default.
- W2306937125 cites W1579040796 @default.
- W2306937125 cites W1603947018 @default.
- W2306937125 cites W1610977048 @default.
- W2306937125 cites W1903728183 @default.
- W2306937125 cites W1967684747 @default.
- W2306937125 cites W1971296064 @default.
- W2306937125 cites W1977495682 @default.
- W2306937125 cites W1980609328 @default.
- W2306937125 cites W1985925852 @default.
- W2306937125 cites W1987653836 @default.
- W2306937125 cites W1996641704 @default.
- W2306937125 cites W2005749628 @default.
- W2306937125 cites W2049770869 @default.
- W2306937125 cites W2056055245 @default.
- W2306937125 cites W2063397275 @default.
- W2306937125 cites W2074697458 @default.
- W2306937125 cites W2075593090 @default.
- W2306937125 cites W2076943035 @default.
- W2306937125 cites W2086122328 @default.
- W2306937125 cites W2088240444 @default.
- W2306937125 cites W2095315186 @default.
- W2306937125 cites W2140093413 @default.
- W2306937125 cites W2243300528 @default.
- W2306937125 cites W2341102993 @default.
- W2306937125 cites W2402722883 @default.
- W2306937125 cites W2413980472 @default.
- W2306937125 cites W2416077098 @default.
- W2306937125 cites W2419742715 @default.
- W2306937125 cites W2424133290 @default.
- W2306937125 cites W1969780327 @default.
- W2306937125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9321518" @default.
- W2306937125 hasPublicationYear "1997" @default.
- W2306937125 type Work @default.
- W2306937125 sameAs 2306937125 @default.
- W2306937125 citedByCount "8" @default.
- W2306937125 countsByYear W23069371252013 @default.
- W2306937125 countsByYear W23069371252016 @default.
- W2306937125 crossrefType "journal-article" @default.
- W2306937125 hasAuthorship W2306937125A5004489015 @default.
- W2306937125 hasAuthorship W2306937125A5050017752 @default.
- W2306937125 hasAuthorship W2306937125A5059001915 @default.
- W2306937125 hasAuthorship W2306937125A5061422874 @default.
- W2306937125 hasAuthorship W2306937125A5087288886 @default.
- W2306937125 hasConcept C14471203 @default.
- W2306937125 hasConcept C161790260 @default.
- W2306937125 hasConcept C171305022 @default.
- W2306937125 hasConcept C181199279 @default.
- W2306937125 hasConcept C185592680 @default.
- W2306937125 hasConcept C190283241 @default.
- W2306937125 hasConcept C2778113725 @default.
- W2306937125 hasConcept C2779384962 @default.
- W2306937125 hasConcept C2780768313 @default.
- W2306937125 hasConcept C29311851 @default.
- W2306937125 hasConcept C50605568 @default.
- W2306937125 hasConcept C526171541 @default.
- W2306937125 hasConcept C55493867 @default.
- W2306937125 hasConcept C86745063 @default.
- W2306937125 hasConcept C87644729 @default.
- W2306937125 hasConceptScore W2306937125C14471203 @default.
- W2306937125 hasConceptScore W2306937125C161790260 @default.
- W2306937125 hasConceptScore W2306937125C171305022 @default.
- W2306937125 hasConceptScore W2306937125C181199279 @default.
- W2306937125 hasConceptScore W2306937125C185592680 @default.
- W2306937125 hasConceptScore W2306937125C190283241 @default.
- W2306937125 hasConceptScore W2306937125C2778113725 @default.
- W2306937125 hasConceptScore W2306937125C2779384962 @default.
- W2306937125 hasConceptScore W2306937125C2780768313 @default.
- W2306937125 hasConceptScore W2306937125C29311851 @default.
- W2306937125 hasConceptScore W2306937125C50605568 @default.
- W2306937125 hasConceptScore W2306937125C526171541 @default.
- W2306937125 hasConceptScore W2306937125C55493867 @default.
- W2306937125 hasConceptScore W2306937125C86745063 @default.
- W2306937125 hasConceptScore W2306937125C87644729 @default.
- W2306937125 hasIssue "10" @default.
- W2306937125 hasLocation W23069371251 @default.
- W2306937125 hasOpenAccess W2306937125 @default.
- W2306937125 hasPrimaryLocation W23069371251 @default.
- W2306937125 hasRelatedWork W2010701693 @default.
- W2306937125 hasRelatedWork W2023087412 @default.
- W2306937125 hasRelatedWork W2024923706 @default.
- W2306937125 hasRelatedWork W2027175203 @default.
- W2306937125 hasRelatedWork W2067042487 @default.
- W2306937125 hasRelatedWork W2074990023 @default.
- W2306937125 hasRelatedWork W2161569589 @default.
- W2306937125 hasRelatedWork W2306937125 @default.