Matches in SemOpenAlex for { <https://semopenalex.org/work/W2306977323> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2306977323 abstract "Background : The present study was performed to further improve our understanding of molecular mechanisms involved in the activation of NFkB, a major transcriptional factor involved in the inflammatory response in the lung, by particulate matter in lung epithelial cells with an aerodynamic diameter of less than (PM2.5). Materials and Methods : Immediate production of reactive oxygen species (ROS) and nitrogen species (RNS), with the PM2.5 induced expression of inducible nitric oxide synthase (iNOS), degradation and -dependent transcriptional activity, in 549 cells, were monitored. Addition, we also examined the effect of the iNOS inhibitor, L-N6-(1-iminoethyl) lysine hydrochloride (L-NIL), on the PM2.5-induced activation in A549 cells. Results : The rapid degradation of and the increase of transcriptional activity of the -dependent promotor were observed in A549 cells exposed to PM2.5. The immediate production of ROS in response to PM2.5 in A549 cells was not clearly detected, although immediate responses were observed in RAW264.7 cells. A 549 cells, cultured in the presence of PM2.5, produced an increase in NO, which was noticeably significant after 15 min of exposure with the expression of iNOS mRNA. The addition of L-NIL, an iNOS inhibitor, significantly inhibited the PM2.5-induced degradation and the increase of the -dependent transcriptional activity. Conclusion : These results suggest that PM2.5 stimulates the immediate production of RNS, leading to the activation of in the pulmonary epithelium." @default.
- W2306977323 created "2016-06-24" @default.
- W2306977323 creator A5015481616 @default.
- W2306977323 creator A5039461107 @default.
- W2306977323 creator A5053776224 @default.
- W2306977323 creator A5066087912 @default.
- W2306977323 creator A5085106382 @default.
- W2306977323 creator A5089136184 @default.
- W2306977323 date "2002-01-01" @default.
- W2306977323 modified "2023-09-23" @default.
- W2306977323 title "Role of NO in Activation of NFκB by PM 2.5 in Lung Epithelial Cells" @default.
- W2306977323 doi "https://doi.org/10.4046/trd.2002.52.6.616" @default.
- W2306977323 hasPublicationYear "2002" @default.
- W2306977323 type Work @default.
- W2306977323 sameAs 2306977323 @default.
- W2306977323 citedByCount "0" @default.
- W2306977323 crossrefType "journal-article" @default.
- W2306977323 hasAuthorship W2306977323A5015481616 @default.
- W2306977323 hasAuthorship W2306977323A5039461107 @default.
- W2306977323 hasAuthorship W2306977323A5053776224 @default.
- W2306977323 hasAuthorship W2306977323A5066087912 @default.
- W2306977323 hasAuthorship W2306977323A5085106382 @default.
- W2306977323 hasAuthorship W2306977323A5089136184 @default.
- W2306977323 hasConcept C126322002 @default.
- W2306977323 hasConcept C153911025 @default.
- W2306977323 hasConcept C203014093 @default.
- W2306977323 hasConcept C2776914184 @default.
- W2306977323 hasConcept C2777622882 @default.
- W2306977323 hasConcept C2777714996 @default.
- W2306977323 hasConcept C2777730290 @default.
- W2306977323 hasConcept C2779525624 @default.
- W2306977323 hasConcept C48349386 @default.
- W2306977323 hasConcept C519581460 @default.
- W2306977323 hasConcept C71924100 @default.
- W2306977323 hasConcept C81729549 @default.
- W2306977323 hasConcept C86803240 @default.
- W2306977323 hasConcept C87568996 @default.
- W2306977323 hasConcept C95444343 @default.
- W2306977323 hasConceptScore W2306977323C126322002 @default.
- W2306977323 hasConceptScore W2306977323C153911025 @default.
- W2306977323 hasConceptScore W2306977323C203014093 @default.
- W2306977323 hasConceptScore W2306977323C2776914184 @default.
- W2306977323 hasConceptScore W2306977323C2777622882 @default.
- W2306977323 hasConceptScore W2306977323C2777714996 @default.
- W2306977323 hasConceptScore W2306977323C2777730290 @default.
- W2306977323 hasConceptScore W2306977323C2779525624 @default.
- W2306977323 hasConceptScore W2306977323C48349386 @default.
- W2306977323 hasConceptScore W2306977323C519581460 @default.
- W2306977323 hasConceptScore W2306977323C71924100 @default.
- W2306977323 hasConceptScore W2306977323C81729549 @default.
- W2306977323 hasConceptScore W2306977323C86803240 @default.
- W2306977323 hasConceptScore W2306977323C87568996 @default.
- W2306977323 hasConceptScore W2306977323C95444343 @default.
- W2306977323 hasLocation W23069773231 @default.
- W2306977323 hasOpenAccess W2306977323 @default.
- W2306977323 hasPrimaryLocation W23069773231 @default.
- W2306977323 hasRelatedWork W1965530345 @default.
- W2306977323 hasRelatedWork W2003950446 @default.
- W2306977323 hasRelatedWork W2004653738 @default.
- W2306977323 hasRelatedWork W2030470859 @default.
- W2306977323 hasRelatedWork W2044930099 @default.
- W2306977323 hasRelatedWork W2081323829 @default.
- W2306977323 hasRelatedWork W2160296782 @default.
- W2306977323 hasRelatedWork W2473767673 @default.
- W2306977323 hasRelatedWork W2586124333 @default.
- W2306977323 hasRelatedWork W2601906920 @default.
- W2306977323 hasRelatedWork W2789190892 @default.
- W2306977323 hasRelatedWork W2892133203 @default.
- W2306977323 hasRelatedWork W2898460937 @default.
- W2306977323 hasRelatedWork W2901959612 @default.
- W2306977323 hasRelatedWork W2911267231 @default.
- W2306977323 hasRelatedWork W2912103464 @default.
- W2306977323 hasRelatedWork W3082641911 @default.
- W2306977323 hasRelatedWork W3130933034 @default.
- W2306977323 hasRelatedWork W3147487281 @default.
- W2306977323 hasRelatedWork W3208219538 @default.
- W2306977323 isParatext "false" @default.
- W2306977323 isRetracted "false" @default.
- W2306977323 magId "2306977323" @default.
- W2306977323 workType "article" @default.